NEJM:人工胰腺系统用于I型糖尿病患儿的治疗

2020-08-27 MedSci原创 MedSci原创

近日研究人员考察了人工胰腺闭环胰岛素给药系统对I型糖尿病儿童血糖的影响。

近日研究人员考察了人工胰腺闭环胰岛素给药系统对I型糖尿病儿童血糖的影响。
 
 
本次研究是为期16周的多中心、随机、开放标签、平行试验, 6至13岁的I型糖尿病患儿参与,随机接受人工胰腺胰岛素传递闭环系统(闭环组)或传感器增强型胰岛素泵(对照组)治疗。 研究的主要结果是葡萄糖水平在每分升70至180毫克目标范围内的时间百分比。
 
101名患儿参与研究,其中闭环组78名,对照组23名,基线糖化血红蛋白水平在5.7%至10.1%之间。在闭环组中,血糖水平维持在70至180毫克/分升目标范围的时间百分比从基线时的53%增加到67%,而对照组从51%增加到55%(平均差异11%)。
两组中,血糖水平低于70毫克每分升的时间百分比均较低,其中闭环组为1.6%,对照组为1.8%。在闭环组,系统处于闭环模式的时间中位数百分比为93%。两组均未发生糖尿病酮症酸中毒或严重的低血糖
 
对于患有I型糖尿病的儿童,使用人工胰腺闭环系统后,血糖维持效果优于使用传感器增强型胰岛素泵。
 
原始出处:
 
Marc D. Breton et al. A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes. N Engl J Med, August 27, 2020.

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    2020-08-28 小小住院医

    学习

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    2020-08-28 智者为医08
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    2020-08-27 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1539544, encodeId=eb341539544f1, content=<a href='/topic/show?id=46002486293' target=_blank style='color:#2F92EE;'>#人工胰腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24862, encryptionId=46002486293, topicName=人工胰腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Aug 29 09:57:04 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814450, encodeId=63c081445066, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200828/11010844155c4b71a324b97f4845c29b/b3866ff93d2f4ba29b7a025832db1c04.jpg, createdBy=e6b62392457, createdName=小小住院医, createdTime=Fri Aug 28 07:32:08 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814396, encodeId=0f6d8143968c, content=<a href='/topic/show?id=63362486386' target=_blank style='color:#2F92EE;'>#人工胰腺系统#</a>用于<a href='/topic/show?id=4f00101e8a6' target=_blank style='color:#2F92EE;'>#I型糖尿病#</a>患儿的治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24863, encryptionId=63362486386, topicName=人工胰腺系统), TopicDto(id=10178, encryptionId=4f00101e8a6, topicName=I型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Aug 28 00:36:56 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035395, encodeId=6d89103539530, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Aug 27 21:57:04 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043299, encodeId=08a51043299d1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Aug 27 21:57:04 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814296, encodeId=4f5781429663, content=对于I型糖尿病来说,是个好消息。<a href='/topic/show?id=4f00101e8a6' target=_blank style='color:#2F92EE;'>#I型糖尿病#</a><a href='/topic/show?id=63362486386' target=_blank style='color:#2F92EE;'>#人工胰腺系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10178, encryptionId=4f00101e8a6, topicName=I型糖尿病), TopicDto(id=24863, encryptionId=63362486386, topicName=人工胰腺系统)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Aug 27 20:58:38 CST 2020, time=2020-08-27, status=1, ipAttribution=)]
    2020-08-27 misszhang

    谢谢MedSci提供最新的资讯

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    2020-08-27 Jessica

    对于I型糖尿病来说,是个好消息。#I型糖尿病##人工胰腺系统#

    0

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