Nature Neurosci—MRI可预测多种精神疾病

中文摘要

观察研究报告了脑成像衍生表型（IDPs）与精神疾病之间的相关性；然而，这些关系是否是因果关系尚不确定。研究人员进行了双向双样本孟德尔随机化（MR）分析，以探讨587个可靠的IDP（N=33224人）和10种精神疾病（N=9725至161405人）之间的因果关系。他们确定了9种IDP，有证据表明其对精神分裂症、神经性厌食症和双相情感障碍的风险有因果影响。例如，胼胝体辐射线枕部的定向分散指数每增加1s.d，精神分裂症风险降低32%。而反向MR显示，只有遗传预测的精神分裂症与两种IDP呈正相关，即皮质表面积和右眶部体积。他们建立了BrainMR数据库（http://www.bigc.online/BrainMR/）分享他们的研究结果。他们的发现为在脑成像水平上预测和干预精神障碍疾病提供潜在的策略。

英文摘要

Observational studies have reported the correlations between brain imaging-derived phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal is uncertain. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to explore the causalities between 587 reliable IDPs (N = 33,224 inpiduals) and 10 psychiatric disorders (N = 9,725 to 161,405). We identified nine IDPs for which there was evidence of a causal influence on risk of schizophrenia, anorexia nervosa and bipolar disorder. For example, 1 s.d. increase in the orientation dispersion index of the forceps major was associated with 32% lower odds of schizophrenia risk. Reverse MR indicated that only genetically predicted schizophrenia was positively associated with two IDPs, the cortical surface area and the volume of the right pars orbitalis. We established the BrainMR database ( http://www.bigc.online/BrainMR/ ) to share our results. Our findings provide potential strategies for the prediction and intervention for psychiatric disorder risk at the brain-imaging level.