JAHA:大便隐血与缺血性卒中和心肌梗塞风险增加相关

2020-12-30 MedSci原创 MedSci原创

FIT阳性结果与缺血性卒中、MI和死亡率相关。大便隐血可能比其在CRC筛查中众所周知的临床意义提供了更多的信息。

尽管大便中隐血被普遍认为是大肠癌(CRC)的筛查工具,但只有很少的研究调查了粪便免疫化学检查(FIT)在其他疾病中的临床意义。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了FIT在心血管疾病(即缺血性卒中和心肌梗塞[MI])患者中的临床效用。

研究人员使用国家健康保险数据库,对2009年至2012年期间具有CRC筛查记录的参与者(年龄>50岁)进行筛选并随访。有心血管疾病和CRC史的受试者被排除在外。缺血性卒中、MI和其他合并症是由《国际疾病分类第十修订版》(ICD-10)代码来进行定义的。在多变量分析中调整了年龄、性别、吸烟、饮酒、规律运动、糖尿病、高血压、血脂异常和体重指数。

该研究共有6277446名受试者符合分析条件。在平均6.79年的随访期间,168570名参与者发生了缺血性卒中,105983名参与者发生了MI,并观察到11253例死亡。多元校正模型显示,FIT阳性人群缺血性卒中的风险较高(校正风险比[HR]为1.09;95%CI为1.07-1.11)。同样,FIT阳性受试者发生MI的风险增加(校正后的HR为1.09;95%CI为1.06-1.12)。此外,在FIT阳性人群中观察到全因死亡率增加(调整后的HR为1.15;95%CI为1.07-1.23)。在对贫血和CRC状态的分层分析中,增加的风险保持一致。

由此可见,FIT阳性结果与缺血性卒中、MI和死亡率相关。大便隐血可能比其在CRC筛查中众所周知的临床意义提供了更多的信息。

原始出处:

Jung Min Moon.et al.Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017783

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    2021-01-05 Jessica

    大便隐血与缺血性卒中和心肌梗塞风险增加相关

    0

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    2020-12-31 zhaohui6731
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    2020-12-30 WL

    还是不能分享QQ空间吗?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1893345, encodeId=68bd1893345e6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Nov 07 16:41:35 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806416, encodeId=9462180641623, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat May 08 03:41:35 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913849, encodeId=29c691384973, content=大便隐血与缺血性卒中和心肌梗塞风险增加相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Jan 05 11:09:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268380, encodeId=88791268380c1, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Dec 31 23:41:35 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912141, encodeId=b35f91214158, content=还是不能分享QQ空间吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Wed Dec 30 13:28:24 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912134, encodeId=ec9b91213469, content=每一个临床细节都是疾病的反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201225/6e1ef4f864494d0284b9282bc4cafc19/f7f10a42767b46c9823f11c34f905873.jpg, createdBy=145f5447474, createdName=ms6000001700483633, createdTime=Wed Dec 30 13:06:52 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026733, encodeId=58571026e33e5, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Dec 30 11:41:35 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912113, encodeId=0ba991211333, content=临床意义不大,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 30 10:54:08 CST 2020, time=2020-12-30, status=1, ipAttribution=)]
    2020-12-30 ms6000001700483633

    每一个临床细节都是疾病的反应

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1893345, encodeId=68bd1893345e6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Nov 07 16:41:35 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806416, encodeId=9462180641623, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat May 08 03:41:35 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913849, encodeId=29c691384973, content=大便隐血与缺血性卒中和心肌梗塞风险增加相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Jan 05 11:09:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268380, encodeId=88791268380c1, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Dec 31 23:41:35 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912141, encodeId=b35f91214158, content=还是不能分享QQ空间吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Wed Dec 30 13:28:24 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912134, encodeId=ec9b91213469, content=每一个临床细节都是疾病的反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201225/6e1ef4f864494d0284b9282bc4cafc19/f7f10a42767b46c9823f11c34f905873.jpg, createdBy=145f5447474, createdName=ms6000001700483633, createdTime=Wed Dec 30 13:06:52 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026733, encodeId=58571026e33e5, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Dec 30 11:41:35 CST 2020, time=2020-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912113, encodeId=0ba991211333, content=临床意义不大,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 30 10:54:08 CST 2020, time=2020-12-30, status=1, ipAttribution=)]
    2020-12-30 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2020-12-30 yangchou

    临床意义不大,学习了

    0

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