Clin Chem:控制大麻吸入后Δ9-Tetrahydrocannabinol浓度和释放动力学的相关性

2019-10-19 gladiator MedSci原创

众所周知,使用大麻会影响驾驶,并增加车祸的风险。大麻素在血液和其他基质中的浓度在使用后很长一段时间内都保持在较高水平,这就对急性和慢性接触的区分非常困难。呼气被认为是一种替代基质,其中浓度可能更接近于损伤窗口;然而,有效的捕获和分析灵敏的检测方法仍需要进一步评估。<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt

众所周知,使用大麻会影响驾驶,并增加车祸的风险。大麻素在血液和其他基质中的浓度在使用后很长一段时间内都保持在较高水平,这就对急性和慢性接触的区分非常困难。呼气被认为是一种替代基质,其中浓度可能更接近于损伤窗口;然而,有效的捕获和分析灵敏的检测方法仍需要进一步评估。

本研究收集20名志愿者在控制服用大麻前后的血液和呼吸样本。用LC-MS/MS测定大麻素浓度,确定释放动力学和两种基质之间的相关性。

吸食大麻后3小时以后,能在所有个体的呼出气体中检测到Δ9-Tetrahydrocannabinol (THC)。在15分钟时间点呼吸中THC浓度最高(中位值为17.8 pg/L),并在3小时后下降到该浓度的5%。观察到的血液和呼吸的衰减曲线与群体中的个体高度相关。

研究表明,在控制吸用大麻后,THC可以可靠地检测到整个3-h损伤窗口。尽管检测窗口较短,这些发现支持呼吸THC浓度代表一个生理过程,并与血液浓度相关。

原始出处:

Kara L. Lynch, Y. Ruben Luo,Correlation of Breath and Blood Δ9-Tetrahydrocannabinol Concentrations and Release Kinetics Following Controlled Administration of Smoked Cannabis

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    2020-03-04 bsmagic9140
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    2020-05-09 smlt2008
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    2020-07-29 linlin2312
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    2020-07-03 yhy100200
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    2019-10-21 kcb069
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