Diabetes Care:"神药"二甲双胍可促进肠道将血糖排到粪便中

2020-06-27 MedSci原创 MedSci原创

二甲双胍治疗与肠腔内空间[18F]FDG积累增加有关,表明这种药物促进了葡萄糖从血液循环进入粪便的运输。

正电子发射断层扫描(PET)-计算机断层扫描显示,二甲双胍可促进肠道积累[18F]氟脱氧葡萄糖(FDG),这是一种非代谢的葡萄糖。然而,至今为止,我们对于这种积累是发生在肠壁还是肠腔内空间仍然未知。

最近,研究人员采用[18F]FDG PET-MRI解决了这一问题,这是最近发展起来的一种成像方法,具有更高的注册精度和高软组织对比度。

在244名接受PET-MRI的2型糖尿病患者中,研究人员提取了24对年龄、BMI和HbA1c水平相匹配的受试者,他们正在接受二甲双胍治疗(二甲双胍组)或没有接受治疗(对照组)。研究人员用视觉标尺和最大标准化摄取值(SUVmax)的测量来评估[18F]FDG在肠道不同部位的积累,这种在肠壁或肠腔内的积累是根据SUVmax来区分的。

结果显示,二甲双胍组的空肠、回肠和右/左半结肠的SUVmax大于对照组。用视觉标尺评估回肠和右/左半结肠的[18F]FDG积累时,二甲双胍组也更多。二甲双胍组回肠和右/左半结肠腔内空间的SUVmax大于对照组,但肠壁的SUVmax并没有大于对照组。

因此,二甲双胍治疗与肠腔内空间[18F]FDG积累增加有关,表明这种药物促进了葡萄糖从血液循环进入粪便的运输。

 

原始出处:

Yasuko Morita et al. Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [ 18 F]Fluorodeoxyglucose PET-MRI , Diabetes Care (2020). DOI: 10.2337/dc20-0093

 

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    2020-06-29 Homburg
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    2020-06-27 misszhang

    二甲双胍,神药!

    0

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    2020-06-27 mswert122

    #二甲双胍#神药在发挥作用。

    0

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