Br J Cancer：宫颈癌筛查对宫颈癌死亡率有什么影响？

2016-09-26 Moon 译 MedSci原创

毫无疑问，对宫颈癌筛查可以预防宫颈癌，但是定期筛查对宫颈癌死亡率的影响又怎样？目前仍是未知的。基于人群的病例对照研究，采用了英国1988-2013年的前瞻性宫颈筛查数据。2007年4月至2013年3月，共有11619名妇女诊断为宫颈癌，年龄25-79岁。对每一例宫颈癌患者按年龄匹配两例非癌症对照组。使用条件逻辑回归估计阶段特定癌症的比值比(OR)（前15年时间里定期筛查 vs 不筛查；不定

毫无疑问，对宫颈癌筛查可以预防宫颈癌，但是定期筛查对宫颈癌死亡率的影响又怎样？目前仍是未知的。

基于人群的病例对照研究，采用了英国1988-2013年的前瞻性宫颈筛查数据。2007年4月至2013年3月，共有11619名妇女诊断为宫颈癌，年龄25-79岁。对每一例宫颈癌患者按年龄匹配两例非癌症对照组。使用条件逻辑回归估计阶段特定癌症的比值比(OR)（前15年时间里定期筛查 vs 不筛查；不定期筛查 vs 不筛查）。

数据显示，35-64岁女性的定期宫颈癌筛查，可以降低67%的1A期宫颈癌发生率（95% CI 62-73%），以及降低95%的3期或更严重的宫颈癌发生率(95% CI: 94-97%)。定期进行宫颈癌筛查（≤5.5年）的女性与没有进行宫颈癌筛查的女性相比，癌症发生率的OR值为0.18 (95% CI: 0.16-0.19)，死亡率的OR值为0.08 (95% CI: 0.07-0.09)。

据估计，英国目前宫颈癌筛查可以预防70% (95% CI: 66-73%)的宫颈癌死亡；如果每个人都定期进行宫颈癌筛查，那么这一数据将会变为83% (95% CI: 82-84%)。

宫颈癌筛查和高级别宫颈癌发病率之间的关联是十分强烈的，宫颈癌筛查可有效预防死亡！

原始出处：

Landy R.et al.Impact of cervical screening on cervical cancer mortality: estimation using stage-specific results from a nested case-control study.Br J Cancer. 2016 Sep 15. doi: 10.1038/bjc.2016.290. [Epub ahead of print]

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2016-09-28 一闲

#宫颈#

28 0
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2016-09-28 般若傻瓜

#宫颈癌筛查#

32 0
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2016-09-27 医路开来

谢谢分享，，。

65 0
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2016-09-27 医路开来

谢谢分享，，，

54 0
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2016-09-27 医路开来

学习啦，，，

59 0
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2016-09-27 刘煜

学习了谢谢。

55 0
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2016-09-26 lovetcm

筛查是相当有效，对进展快的肿瘤有更大的获益

60 0
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2016-09-26 lhl629

内容很不错，谢谢分享。

24 0

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