J Allergy Clin Immunol:鼻息肉慢性鼻窦炎患者中免疫球蛋白G能够调控促炎性lgE响应

2019-03-01 AlexYang MedSci原创

鼻息肉慢性鼻窦炎(CRSwNP)通常可以通过多克隆lgE个体基因型的局部产生来鉴定。虽然组织lgE浓度能够达到几千kU/L,鼻息肉中lgE调节的炎症是通过怎样的机制来调控的仍旧不清楚。最近,有研究人员探索了是否鼻息肉中局部诱导的lgG抗体能够抑制lgE调节的促炎性响应。研究人员从草花粉过敏的CRSwNP和非过敏性对照受试者中采集了鼻息肉匀浆。研究发现,鼻息肉中,lgG在控制lgE调节的炎症响应方面

鼻息肉慢性鼻窦炎(CRSwNP)通常可以通过多克隆lgE个体基因型的局部产生来鉴定。虽然组织lgE浓度能够达到几千kU/L,鼻息肉中lgE调节的炎症是通过怎样的机制来调控的仍旧不清楚。

最近,有研究人员探索了是否鼻息肉中局部诱导的lgG抗体能够抑制lgE调节的促炎性响应。研究人员从草花粉过敏的CRSwNP和非过敏性对照受试者中采集了鼻息肉匀浆。研究发现,鼻息肉中,lgG在控制lgE调节的炎症响应方面具有关键的作用。鼻肉匀浆中lgG的缺失能够导致CD23调节的lgE促进性过敏原与B细胞结合的增加(lgE-FAB),同时提高了的FcεRI调节的过敏原能够驱使嗜碱性细胞的激活和组胺释放。研究人员在特异性lgE抗体对金黄色酿脓葡萄球菌(SE-lgE)中观察到乐儿相似的响应。另外,在过敏性和非过敏性鼻炎受试者中,鼻息肉中lgG限制lgE调节炎症的能力是基于lgG与lgE广泛的使用相同的抗原靶标。

最后,研究人员指出,CRSwNP中的lgE多克隆基因型是具有功能的,能够促进lgE调节的促过敏性炎症,并且与lgG存在部分的拮抗作用。

原始出处:

Shamji MH, Thomsen I, Layhadi J et al. Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses. J Allergy Clin Immunol. 11 Feb 2019.

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    2019-07-05 xzw113
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    2019-03-03 膀胱癌
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    2019-03-03 HNYYM

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