Otolaryngol Head Neck Surg:凝血弹性描记法评估突发性感音神经性听力损失患者的凝血状态

2020-11-22 AlexYang MedSci原创

突发性感音神经性听力损失(SSNHL)患者的凝血状态是有争议的。最近,有研究人员使用凝血弹性描记法(TEG)调查了血液凝固参数与SSNHL发病和恢复之间的关系。

突发性感音神经性听力损失(SSNHL)患者的凝血状态是有争议的。最近,有研究人员使用凝血弹性描记法(TEG)调查了血液凝固参数与SSNHL发病和恢复之间的关系。

研究是一个前瞻性研究,地点为上海交通大学附属第六人民医院。研究共招募了104名新诊断的SSNHL患者和29名匹配的健康对照。研究人员进行了听力评估、TEG和常规凝血试验(CCT),之后进行了标准治疗和随访。研究发现,SSNHL患者的TEG参数在正常范围内,但与对照组相比,该组的动力学时间明显延长(K;P=0.004)且角度更小(P=0.003)。根据听觉图对SSNHL患者进行分组并成对比较后,研究人员发现只有当对照组与低频SSNHL患者(K,P=0.023;角度,P=0.04)和平型SSNHL(K,P=0.017;角度,P=0.014)患者进行比较时才有显著差异。逻辑回归分析显示,TEG和CCT参数均未显著影响SSNHL治疗后的听力改善。

听力恢复于TEG和CCT参数的相关性

最后,研究人员指出,虽然与对照组相比,试验组的K值和角度分别显著升高和显著减少,但SSNHL患者的凝血状态仍在正常范围内。各组患者根据听力恢复状态,CCT、TEG凝血参数(除角度外)均无明显差异,表明了凝血状态并不能确定SSNHL患者的预后。

原始出处:

Chunyan Li , Huiqun Zhou , Yanmei Feng et al. Coagulation States in Patients With Sudden Sensorineural Hearing Loss Evaluated by Thromboelastography. Otolaryngol Head Neck Surg. Nov 2020

 

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