JCEM:青春期BMI变化是男性成人2型糖尿病风险的重要决定因素

2018-12-05 xing.T MedSci原创

由此可见,青春期BMI变化是男性成人2型糖尿病风险一个重要的,而儿童BMI是一个中等的独立决定因素。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究的目的是确定青春期体重指数(BMI)变化对成年男性2型糖尿病风险中的作用,而不考虑儿童期超重。

研究人员纳入了36176名男性,他们在8岁(儿童)和20岁(年轻成人)时测量了体重和身高,可从BMI流行病学研究(BEST)和征兵登记处获取数据。从瑞典国家患者登记处检索了关于2型糖尿病患者(n=1777)的信息。通过Cox回归估计危险比和95%置信区间,包括出生年份和出生国家在内的变量作为协变量。由于青春期BMI变化与2型糖尿病之间的关联违反了比例风险的假设,研究人员将随访时间分为早期(≤55.7岁)和晚期(>55.7岁)。

青春期的儿童超重和较高BMI与成人2型糖尿病的风险相关。男孩超重但在青春期正常的男性患2型糖尿病的风险并未显著增加(早期2型糖尿病为1.28 [0.89-1.82];晚期2型糖尿病为1.35 [0.97-1.87])。在青春期发展为超重的男性中(早期2型糖尿病为4.67[3.90-5.58];晚期2型糖尿病为2.85[2.25-3.61])和在儿童期和成年早期超重的男性中(早期2型糖尿病为4.82[3.84-6.05];晚期2型糖尿病为3.04[2.27-4.06])与从未超重的男性相比,患2型糖尿病的风险显著增加。

由此可见,青春期BMI变化是男性成人2型糖尿病风险一个重要的,而儿童BMI是一个中等的独立决定因素。

原始出处:

Claes Ohlsson,et al.BMI change during puberty is an important determinant of adult type 2 diabetes risk in men.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2018-01339

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    2019-10-29 achengzhao
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    2019-10-04 smallant2015
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    2018-12-05 misszhang

    谢谢MedSci提供最新的资讯

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