ASCO 2022:低钠血症可能预示着更糟糕的结果,胃癌患者需警惕!

2022-06-02 MedSci原创 MedSci原创

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以往研究报道显示,低钠血症会增加实体瘤患者的死亡率和住院时间。然而,很少有低钠血症与胃癌相关的报道。来自美国圣何塞州立大学研究人员评估了低钠血症对胃癌患者的死亡率和发病率的影响。

在这项研究中,研究人员使用国际疾病分类 10 (ICD-10)调查了 2019 年全国住院患者样本,包括成年胃癌患者。使用多变量逻辑和线性回归分析调整混杂变量,包括性别、种族、Charlson合并症指数、慢性肾病、充血性心力衰竭、肝硬化、肾病综合征、甲状腺功能减退、肾上腺功能不全、酒精使用障碍、因血容量不足或精神性多尿症入院以及各种病人和医院特征。

近期,研究人员在ASCO大会上公布了研究结果,胃癌患者低钠血症的患病率为 13.59%,低钠血症导致院内死亡率增加。

具体而言,共有43015名胃癌患者,13.59%出现低钠血症。合并低钠血症胃癌患者的住院死亡率为 12.23%,而无低钠血症的胃癌患者为 6.69%。调整混杂因素后,低钠血症带来更高的死亡率。

另外,低钠血症还增加了住院时间、住院费用和进入ICU的几率,平均住院时间增加2.09天,平均住院费用总额增加22320美元。 此外,低钠血症患者出现急性肾衰竭的几率更高。两个研究组的脑水肿和精神状态改变发生率相等(P > 0.05)。

总之,胃癌患者发生低钠血症几率为13.59%,同时增加了死亡风险。那么,低钠血症的高效治疗是否有助于降低死亡率和改善预后仍有待未来研究确定。

原始出处

Jorge Franco, Diana Franco, Umer Farooq, Irene Ma.Does hyponatremia predict worse outcomes in gastric cancer?: A nationwide study.

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    2022-06-20 quxin068
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