Lancet:胎盘生长因子检测用于先兆子痫的确诊

2019-05-08 MedSci MedSci原创

研究认为PLGF检测可有效缩短先兆子痫临床确认时间

前瞻性队列研究发现,血管生成因子可作为子痫前期诊断标志物,近日研究人员考察了胎盘生长因子(PlGF,一种血管生成因子)的循环浓度对疑似子痫前期妇女的诊断作用。

成年,妊娠20周0天至妊娠36周6天内,出现疑似先兆子痫的妇女参与研究。疑似先兆子痫被定义为现有高血压恶化或新发蛋白尿,上腹部或右上腹疼痛,伴有视觉障碍的头痛,胎儿生长受限或血检异常 (如血小板减少症或肝或肾功能不全)。患者接受PLGF测量或对照。主要的结果是从疑似先兆子痫到确诊先兆子痫的时间。

1023名疑似先兆子痫女性参与研究,576名(56%)妇女被分配到PLGF干预组,447名(44%)妇女被分配接受常规护理,常规组参与者进行隐蔽PLGF测试。先兆子痫诊断中位时间隐蔽试验组为4.1天,干预试验组为1.9天(时间比=0.36)。隐性试验组447例产妇中有24例(5%)出现严重不良反应,而干预试验组573例中有22例(4%,AOR=0.32) 出现严重不良反应。围产期不良后果(15% vs 14%,AOR=1.45)或分娩时妊娠时间(36.6周vs 36.8周)无明显差异。

研究认为PLGF检测可有效缩短先兆子痫临床确认时间。

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    2019-10-13 howi
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