2021年9月11日简报:新冠肺炎重症和死亡可能与自身阻断Ⅰ型干扰素作用的抗体有关;地塞米松不适用于预防新冠肺炎

2021-09-11 MedSci整理 MedSci整理

截至北京时间2021年9月11日7时01分,Worldometers世界实时统计数据显示,全球累计确诊新冠肺炎(COVID-19)病例超过22458万例,新增568,485例,达到224,586,01

截至北京时间2021年9月11日7时01分,Worldometers世界实时统计数据显示,全球累计确诊新冠肺炎COVID-19)病例超过22458万例,新增568,485例,达到224,586,011例。累计死亡病例462.8万例,达到4,628,847例。新增死亡为8,582例。康复为201,111,513例,重症和危重症病人达到103,561例;全球新冠确诊病例超过100万例的国家达35个,106个国家病例超10万例。昨日报道:2021年9月10日简报:中国完成德尔塔灭活疫苗临床前研究;莫德纳宣布研发新冠、流感二合一疫苗;美国75%成年人已至少接种一剂新冠疫苗

世卫组织:地塞米松不适用于预防新冠肺炎

当地时间11日,世卫组织举行新冠肺炎例行发布会,世卫组织卫生紧急项目负责人迈克尔·瑞安表示,地塞米松应在医学监督下使用,不适用于预防新冠肺炎,应该用于新冠肺炎危重症病人。地塞米松是一种非常强力的消炎药,可以挽救肺部和周围血管发炎的重症病人,可能是因为其可以减轻发炎情况,从而保证肺部继续向血液中输送氧气。

法国新增新冠肺炎确诊病例9966例 累计确诊6887791例

法国公共卫生局当地时间9月10日更新的数据显示,法国累计新冠肺炎确诊病例达6887791例,与前一日相比新增确诊病例9966例;新增死亡病例81例,累计死亡115442例。

目前,法国有10115例确诊病例住院接受治疗,过去7天新增入院3651例。其中,接受重症监护的住院病例占到2151例,与前一日相比减少44例

1/5的新冠患者死亡,可能与自身抗体有关

2021年8月16日发表于《科学免疫学》期刊的一项大型国际研究也表明,当一些人感染新冠肺炎后,人体内有一种自身抗体,会攻击自身免疫防御系统,成为导致疾病发展为重症、甚至死亡的关键因素。

有些科学家为了强调其反作用机制,戏称自身抗体为「流氓」抗体。

2020年9月,由纽约洛克菲勒大学让·洛朗·卡萨诺瓦领导的一个研究小组报告显示,987例重症新冠肺炎患者中,超过10%的患者体内出现,攻击自身免疫系统并阻断Ⅰ型干扰素作用的抗体,Ⅰ型干扰素在对抗病毒感染方面有关键作用。

该研究小组专注于检测 「流氓」抗体。他们对38个国家的3595例重症新冠肺炎患者进行研究后发现,有13.6%的患者检测到「流氓」抗体,其中,40岁以下患者的比例为9.6%,80岁以上患者的比例为21%。在死亡患者中有18% 体内存在「流氓」抗体。

他还发现,「流氓」抗体在男性中,比女性中更常见,这可能是男性新冠患者更易得重症的一个因素。

该研究小组专注于检测 「流氓」抗体。他们对38个国家的3595例重症新冠肺炎患者进行研究后发现,有13.6%的患者检测到「流氓」抗体,其中,40岁以下患者的比例为9.6%,80岁以上患者的比例为21%。在死亡患者中有18% 体内存在「流氓」抗体。

3595例重症新冠肺炎患者中有「流氓」抗体的比例

 

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    2021-09-12 **抱抱

    学习了

    0

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    2021-09-11 ms3000001158677026

    地塞米松抗炎、抗毒素、抗过敏、抗休克,是一种强有力的药物。可以减轻患者机体炎性反应和中毒症状,改善通气功能,适合新冠重症患者。抑制机体免疫,无预防应用指证。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1710289, encodeId=2f291e10289fe, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Oct 05 23:47:04 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318238, encodeId=9cc71318238bd, content=<a href='/topic/show?id=685a101e4f8' target=_blank style='color:#2F92EE;'>#I型干扰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10174, encryptionId=685a101e4f8, topicName=I型干扰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Sun Sep 12 21:47:04 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016719, encodeId=da1a1016e1924, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=6cea5423215, createdName=**抱抱, createdTime=Sun Sep 12 10:26:29 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016550, encodeId=f34410165503a, content=地塞米松抗炎、抗毒素、抗过敏、抗休克,是一种强有力的药物。可以减轻患者机体炎性反应和中毒症状,改善通气功能,适合新冠重症患者。抑制机体免疫,无预防应用指证。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58b45602165, createdName=ms3000001158677026, createdTime=Sat Sep 11 14:21:23 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016514, encodeId=a49710165145d, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Sat Sep 11 10:53:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016504, encodeId=0c35101650423, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Sep 11 10:00:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029943, encodeId=7874102994334, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052571, encodeId=75a910525e149, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016487, encodeId=5233101648e63, content=有科研意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJeQVzYNLVuOgFXak5ggibCcpTZWxRex2ZE9xPfjoWUicANF3xWzCvbQn6vogYNKPaYibgc3iavVjha0A/132, createdBy=9e405330080, createdName=文子张张, createdTime=Sat Sep 11 09:04:14 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016464, encodeId=cf5810164648c, content=这个有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Sep 11 08:03:29 CST 2021, time=2021-09-11, status=1, ipAttribution=)]
    2021-09-11 Bureaukey

    优秀

    0

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    2021-09-11 医鸣惊人

    认真学习了

    0

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    2021-09-11 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1710289, encodeId=2f291e10289fe, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Oct 05 23:47:04 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318238, encodeId=9cc71318238bd, content=<a href='/topic/show?id=685a101e4f8' target=_blank style='color:#2F92EE;'>#I型干扰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10174, encryptionId=685a101e4f8, topicName=I型干扰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Sun Sep 12 21:47:04 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016719, encodeId=da1a1016e1924, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=6cea5423215, createdName=**抱抱, createdTime=Sun Sep 12 10:26:29 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016550, encodeId=f34410165503a, content=地塞米松抗炎、抗毒素、抗过敏、抗休克,是一种强有力的药物。可以减轻患者机体炎性反应和中毒症状,改善通气功能,适合新冠重症患者。抑制机体免疫,无预防应用指证。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58b45602165, createdName=ms3000001158677026, createdTime=Sat Sep 11 14:21:23 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016514, encodeId=a49710165145d, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Sat Sep 11 10:53:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016504, encodeId=0c35101650423, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Sep 11 10:00:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029943, encodeId=7874102994334, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052571, encodeId=75a910525e149, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016487, encodeId=5233101648e63, content=有科研意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJeQVzYNLVuOgFXak5ggibCcpTZWxRex2ZE9xPfjoWUicANF3xWzCvbQn6vogYNKPaYibgc3iavVjha0A/132, createdBy=9e405330080, createdName=文子张张, createdTime=Sat Sep 11 09:04:14 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016464, encodeId=cf5810164648c, content=这个有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Sep 11 08:03:29 CST 2021, time=2021-09-11, status=1, ipAttribution=)]
    2021-09-11 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1710289, encodeId=2f291e10289fe, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Oct 05 23:47:04 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318238, encodeId=9cc71318238bd, content=<a href='/topic/show?id=685a101e4f8' target=_blank style='color:#2F92EE;'>#I型干扰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10174, encryptionId=685a101e4f8, topicName=I型干扰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Sun Sep 12 21:47:04 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016719, encodeId=da1a1016e1924, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=6cea5423215, createdName=**抱抱, createdTime=Sun Sep 12 10:26:29 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016550, encodeId=f34410165503a, content=地塞米松抗炎、抗毒素、抗过敏、抗休克,是一种强有力的药物。可以减轻患者机体炎性反应和中毒症状,改善通气功能,适合新冠重症患者。抑制机体免疫,无预防应用指证。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58b45602165, createdName=ms3000001158677026, createdTime=Sat Sep 11 14:21:23 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016514, encodeId=a49710165145d, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=830f2464103, createdName=Bureaukey, createdTime=Sat Sep 11 10:53:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016504, encodeId=0c35101650423, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Sep 11 10:00:09 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029943, encodeId=7874102994334, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052571, encodeId=75a910525e149, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 11 09:47:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016487, encodeId=5233101648e63, content=有科研意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJeQVzYNLVuOgFXak5ggibCcpTZWxRex2ZE9xPfjoWUicANF3xWzCvbQn6vogYNKPaYibgc3iavVjha0A/132, createdBy=9e405330080, createdName=文子张张, createdTime=Sat Sep 11 09:04:14 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016464, encodeId=cf5810164648c, content=这个有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Sep 11 08:03:29 CST 2021, time=2021-09-11, status=1, ipAttribution=)]
    2021-09-11 文子张张

    有科研意义

    0

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    2021-09-11 医者仁者

    这个有价值

    0

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