Brit J Cancer:前列腺癌发生率和死亡率相关的新生化因素调查

2020-10-08 AlexYang MedSci原创

虽然前列腺癌是癌症死亡的主要原因,但其病因学并不十分清楚。最近,有研究人员在英国生物库中鉴定了与前列腺癌发病率和死亡率有关的新型生化因素。

虽然前列腺癌是癌症死亡的主要原因,但其病因学并不十分清楚。最近,有研究人员在英国生物库中鉴定了与前列腺癌发病率和死亡率有关的新型生化因素。

研究人员从招募时多达211754名男子的基线血样和5年后的子样本中测量了一系列血管、骨骼、关节、糖尿病、肾脏和肝脏相关的生物标志物,并通过与健康管理数据集的链接对参与者进行跟踪,从而确定前列腺癌病例。研究人员经过均值为6.9年的随访,确定了5763例前列腺癌病例和331例前列腺癌死亡病例。研究发现,前列腺癌发病率与循环维生素D、尿素和磷酸盐浓度呈正相关,与葡萄糖、总蛋白和天门冬氨酸氨基转移酶呈负相关。在不包括前4年随访的分析中,磷酸盐和胱抑素-C是唯一分别与风险正相关和负相关的生物标志物。另外,几乎没有发现与前列腺癌死亡相关的证据。

敏感性分析

最后,研究人员指出,他们发现几个生物标志物与前列腺癌发病率有新的关联。未来的研究需根据肿瘤的特征来研究相关性。

原始出处:

Aurora Perez-Cornago, Georgina K. Fensom, Colm Andrews et al. Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank. Brit J Cancer. Sep 2020

 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1826640, encodeId=f43e182664027, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Aug 07 03:49:37 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891365, encodeId=ba9989136573, content=前列腺癌新的生化指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Oct 12 06:02:45 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890731, encodeId=fa62890e31b7, content=哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04745411455, createdName=ms3000000546723755, createdTime=Fri Oct 09 09:51:01 CST 2020, time=2020-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040859, encodeId=eeab1040859c6, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Oct 08 13:49:37 CST 2020, time=2020-10-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1826640, encodeId=f43e182664027, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Aug 07 03:49:37 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891365, encodeId=ba9989136573, content=前列腺癌新的生化指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Oct 12 06:02:45 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890731, encodeId=fa62890e31b7, content=哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04745411455, createdName=ms3000000546723755, createdTime=Fri Oct 09 09:51:01 CST 2020, time=2020-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040859, encodeId=eeab1040859c6, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Oct 08 13:49:37 CST 2020, time=2020-10-08, status=1, ipAttribution=)]
    2020-10-12 146465bem06暂无昵称

    前列腺癌新的生化指标

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1826640, encodeId=f43e182664027, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Aug 07 03:49:37 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891365, encodeId=ba9989136573, content=前列腺癌新的生化指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Oct 12 06:02:45 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890731, encodeId=fa62890e31b7, content=哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04745411455, createdName=ms3000000546723755, createdTime=Fri Oct 09 09:51:01 CST 2020, time=2020-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040859, encodeId=eeab1040859c6, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Oct 08 13:49:37 CST 2020, time=2020-10-08, status=1, ipAttribution=)]
    2020-10-09 ms3000000546723755

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1826640, encodeId=f43e182664027, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Aug 07 03:49:37 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891365, encodeId=ba9989136573, content=前列腺癌新的生化指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Oct 12 06:02:45 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890731, encodeId=fa62890e31b7, content=哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04745411455, createdName=ms3000000546723755, createdTime=Fri Oct 09 09:51:01 CST 2020, time=2020-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040859, encodeId=eeab1040859c6, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Oct 08 13:49:37 CST 2020, time=2020-10-08, status=1, ipAttribution=)]
    2020-10-08 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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