BMC Cancer:膀胱癌免疫微环境相关基因分析,可用于预测患者的预后

2020-05-26 MedSci原创 MedSci原创

浸润性免疫细胞和基质细胞是膀胱癌(BC)微环境的重要组成部分,可显著影响BC的进展和结果。然而,肿瘤浸润免疫细胞的每个亚组的贡献尚不清楚。本研究旨在对肿瘤免疫微环境进行细胞表型和转录分析,分析不同细胞

浸润性免疫细胞和基质细胞是膀胱癌(BC)微环境的重要组成部分,可显著影响BC的进展和结果。然而,肿瘤浸润免疫细胞的每个亚组的贡献尚不清楚。本研究旨在对肿瘤免疫微环境进行细胞表型和转录分析,分析不同细胞亚群和基因与BC预后的关联。

 

从The Cancer Genome Atlas中下载了412例BC患者的临床数据和433个正常和癌症组织的转录文件。采用CIBERSORT算法确定每个样本中22种免疫细胞类型的相对丰度,采用ESTIMATE算法确定BC肿瘤微环境中不同表达的基因,并对其进行功能富集和蛋白-蛋白相互作用(PPI)分析。通过Cox回归分析和Kaplan-Meier方法研究了细胞亚群和不同表达基因与患者生存和临床参数的关联。

 

结果显示,静止的自然杀伤细胞和激活的记忆CD4+和CD8+ T细胞与患者的预后良好相关,而静止的记忆CD4+ T细胞与预后不良相关。差异性表达分析显示,影响免疫和基质细胞评分的基因有1334个;其中97个基因对BC患者的总体生存有预测作用。在PPI网络中前10个有统计学意义的枢纽基因中,CXCL12、FN1、LCK和CXCR4被发现与BC预后相关。

 

综上所述,该研究结果表明,肿瘤浸润免疫细胞和肿瘤微环境相关基因可影响患者的预后,可能是BC患者预后和免疫治疗反应的重要决定因素。

 

原始出处:

 

Ye ZhangDe-Hua Ou, et al., In Silico Analysis of the Immune Microenvironment in Bladder Cancer. BMC Cancer. 2020 Mar 30;20(1):265. doi: 10.1186/s12885-020-06740-5.

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    2020-05-26 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

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前列腺腺癌和尿路上皮癌具有典型的不同的形态和免疫组化特性。然而,高等级前列腺癌和尿路上皮癌有时会明显的表现出形态特征和免疫组化特征的重复,从而导致误诊和错误治疗。该诊断瓶颈在之前经历过放疗/激素治疗的

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肌层浸润膀胱癌(MIBCs)是具有侵袭性的生殖泌尿系恶性肿瘤。膀胱的转移性尿路上皮癌在目前的化疗下无法治愈,并且能导致早期死亡。之前的研究鉴定了MIBCs的分子亚型,并且对前线疗法具有不同的敏感性,也

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最近,有研究人员评估了代谢健康状态和膀胱癌发生率之间的相关性,数据来自韩国国家健康保险系统和国家健康检查(NHC)数据库的代表性数据。

Eur Urol:深度学习预测肌层浸润膀胱癌分子亚型

肌层浸润膀胱癌(MIBC)是第二大常见的泌尿生殖系恶性肿瘤,并且与具有高的发病率和死亡率。近期研究人员鉴定了MIBC的分子亚型,这具有重要的临床应用。