J Neurol Neurosur Ps:TIA和轻度卒中白人和中国人颅内动脉狭窄情况比较

2021-03-31 MedSci原创 MedSci原创

中国人比白人对ICAS的易感性更高,发病年龄更早,患病率更高,且独立于血管危险因素。

颅内动脉狭窄(ICAS)是世界范围内导致卒中的重要原因。白人和亚洲人患有卒中/短暂性脑缺血发作(TIA)的个别报告表明,白人ICAS患病率较低,但并没有直接比较这两个人群中ICAS的研究。

近日,神经病学领域权威取杂志Journal Of Neurology Neurosurgery And Psychiatry上发表了一篇研究文章,研究人员对牛津(2011-2018年,主要是白种人)和香港(2011-2015年,主要是中国人)前瞻性招募的2个急性轻微卒中或TIA患者队列进行了比较。

ICAS通过MR/CT血管造影上任何颅内大动脉狭窄/闭塞≥50%来确定。研究人员比较了两组间ICAS的患病率、分布和危险因素,还系统地回顾了不同人群脑卒中/TIA患者ICAS患病率的文献。

在牛津的1287例患者和香港的691例患者中(平均年龄为69岁 vs. 66岁),中国人的ICAS患病率高于白人(43.0% vs. 20.0%;OR为3.02;95%CI为2.47至3.70;p<0.001),且独立于年龄(年龄调整后的OR为3.73;95%CI为3.00至4.63;p<0.001)和血管危险因素(多变量调整OR为3.21;95%CI为2.56至4.02;p<0.001)。在小于70岁的参与者中(OR为5.33;95%CI为3.79至7.50;p<0.001),ICAS患病率的人种差异更大(相互作用p=0.005),相比于70岁以上的参与者(OR为2.81;95%CI为2.11至3.74;p<0.001)。在这两个队列中,ICAS患病率均随年龄和血管危险因素而增加,在60岁以下的中国人和80岁以上的白人以及在没有血管危险因素的中国人和有两个血管危险因素的白人中ICAS患病率相同。中国人和白人在ICAS的位置也有所不同。

由此可见,中国人比白人对ICAS的易感性更高,发病年龄更早,患病率更高,且独立于血管危险因素。

原始出处:

Xinyi Leng.et al.Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review.Journal Of Neurology Neurosurgery And Psychiatry.2021.https://jnnp.bmj.com/content/early/2021/03/30/jnnp-2020-325630

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    2021-11-20 120d521dm50暂无昵称

    好文

    0

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    2021-04-21 yinhl1978
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    2021-04-02 lsndxfj
  5. [GetPortalCommentsPageByObjectIdResponse(id=1661455, encodeId=34181661455f0, content=<a href='/topic/show?id=5f32100380f3' target=_blank style='color:#2F92EE;'>#颅内动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100380, encryptionId=5f32100380f3, topicName=颅内动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c2a25292014, createdName=ms5236388012055669, createdTime=Fri Oct 22 03:05:28 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072295, encodeId=252210e22952a, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3d3b2210771, createdName=120d521dm50暂无昵称, createdTime=Sat Nov 20 18:13:43 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001281, encodeId=7b16200128125, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Apr 21 07:05:28 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364715, encodeId=a2241364e15af, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496933, encodeId=9a5214969334c, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026807, encodeId=42df102680e1e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Mar 31 16:05:28 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952694, encodeId=5296952694db, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 31 16:00:36 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952623, encodeId=abf395262384, content=<a href='/topic/show?id=b86310421ea2' target=_blank style='color:#2F92EE;'>#梅斯私密话题设置#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104217, encryptionId=b86310421ea2, topicName=梅斯私密话题设置)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d3f02433397, createdName=123bef87m55暂无昵称, createdTime=Wed Mar 31 13:37:07 CST 2021, time=2021-03-31, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1661455, encodeId=34181661455f0, content=<a href='/topic/show?id=5f32100380f3' target=_blank style='color:#2F92EE;'>#颅内动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100380, encryptionId=5f32100380f3, topicName=颅内动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c2a25292014, createdName=ms5236388012055669, createdTime=Fri Oct 22 03:05:28 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072295, encodeId=252210e22952a, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3d3b2210771, createdName=120d521dm50暂无昵称, createdTime=Sat Nov 20 18:13:43 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001281, encodeId=7b16200128125, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Apr 21 07:05:28 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364715, encodeId=a2241364e15af, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496933, encodeId=9a5214969334c, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026807, encodeId=42df102680e1e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Mar 31 16:05:28 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952694, encodeId=5296952694db, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 31 16:00:36 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952623, encodeId=abf395262384, content=<a href='/topic/show?id=b86310421ea2' target=_blank style='color:#2F92EE;'>#梅斯私密话题设置#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104217, encryptionId=b86310421ea2, topicName=梅斯私密话题设置)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d3f02433397, createdName=123bef87m55暂无昵称, createdTime=Wed Mar 31 13:37:07 CST 2021, time=2021-03-31, status=1, ipAttribution=)]
    2021-03-31 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1661455, encodeId=34181661455f0, content=<a href='/topic/show?id=5f32100380f3' target=_blank style='color:#2F92EE;'>#颅内动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100380, encryptionId=5f32100380f3, topicName=颅内动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c2a25292014, createdName=ms5236388012055669, createdTime=Fri Oct 22 03:05:28 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1072295, encodeId=252210e22952a, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3d3b2210771, createdName=120d521dm50暂无昵称, createdTime=Sat Nov 20 18:13:43 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001281, encodeId=7b16200128125, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Apr 21 07:05:28 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364715, encodeId=a2241364e15af, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496933, encodeId=9a5214969334c, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Fri Apr 02 04:05:28 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026807, encodeId=42df102680e1e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Mar 31 16:05:28 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952694, encodeId=5296952694db, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 31 16:00:36 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952623, encodeId=abf395262384, content=<a href='/topic/show?id=b86310421ea2' target=_blank style='color:#2F92EE;'>#梅斯私密话题设置#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104217, encryptionId=b86310421ea2, topicName=梅斯私密话题设置)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d3f02433397, createdName=123bef87m55暂无昵称, createdTime=Wed Mar 31 13:37:07 CST 2021, time=2021-03-31, status=1, ipAttribution=)]
    2021-03-31 jyzxjiangqin

    好文章!

    0

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