JAHA:种族、体重指数与房颤风险

2021-01-01 MedSci原创 MedSci原创

肥胖与房颤发生风险增加有关,但体重指数与房颤风险之间的关系呈J型,并且这种关系因人种而异,因此,BMI较高的美籍华裔参与者的房颤风险增加更为明显,而黑人参与者的风险增加最小。

较高的体重指数(BMI)与房颤发生风险增加有关,但尚不清楚这种关系是否因人种而异。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究纳入了多民族动脉粥样硬化研究(MESA)中6739名合格的参与者。研究人员使用MESA医院监视数据、预定的MESA研究心电图数据和Medicare索赔数据对参与者房颤发生情况进行了监测。

在平均随访13.8年后,有970名(14.4%)参与者发生了房颤。在Cox比例风险模型中对BMI进行分类建模时,只有那些II级和III级肥胖的参与者发生房颤的风险增加(II级肥胖参与者的风险比[HR]为1.50;95%CI为1.14–1.98,P=0.004,III级肥胖参与者的HR为2.13;95%CI为1.48-3.05,P<0.0001)。BMI和房颤风险之间的关系呈J型。然而,房颤作为BMI的函数的风险因人种而有很大差异(交互作用P=0.02),BMI较高的华裔美国人房颤风险高得多,而BMI较高的黑人参与者房颤风险最小。

由此可见,肥胖与房颤发生风险增加有关,但体重指数与房颤风险之间的关系呈J型,并且这种关系因人种而异,因此,BMI较高的美籍华裔参与者的房颤风险增加更为明显,而黑人参与者的风险增加最小。

原始出处:

Matthew J. Singleton.et al.Race, Body Mass Index, and the Risk of Atrial Fibrillation: The Multi‐Ethnic Study of Atherosclerosis.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.018592

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  1. [GetPortalCommentsPageByObjectIdResponse(id=913733, encodeId=dd13913e33ce, content=<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a>,胖了哪里都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 22:17:13 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268385, encodeId=fb6612683856f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532027, encodeId=6e26153202ea2, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912923, encodeId=c632912923dc, content=<a href='/topic/show?id=38c16204546' target=_blank style='color:#2F92EE;'>#样条回归#</a>进行趋势分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62045, encryptionId=38c16204546, topicName=样条回归)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jan 01 19:06:26 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031333, encodeId=7aa4103133383, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jan 01 16:09:27 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912882, encodeId=67ae91288235, content=肥胖与房颤发生风险增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=41775447713, createdName=ms6000001359986420, createdTime=Fri Jan 01 14:56:19 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-04 Jessica

    #肥胖#,胖了哪里都不好

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=913733, encodeId=dd13913e33ce, content=<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a>,胖了哪里都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 22:17:13 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268385, encodeId=fb6612683856f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532027, encodeId=6e26153202ea2, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912923, encodeId=c632912923dc, content=<a href='/topic/show?id=38c16204546' target=_blank style='color:#2F92EE;'>#样条回归#</a>进行趋势分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62045, encryptionId=38c16204546, topicName=样条回归)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jan 01 19:06:26 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031333, encodeId=7aa4103133383, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jan 01 16:09:27 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912882, encodeId=67ae91288235, content=肥胖与房颤发生风险增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=41775447713, createdName=ms6000001359986420, createdTime=Fri Jan 01 14:56:19 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-03 zhaohui6731
  3. [GetPortalCommentsPageByObjectIdResponse(id=913733, encodeId=dd13913e33ce, content=<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a>,胖了哪里都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 22:17:13 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268385, encodeId=fb6612683856f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532027, encodeId=6e26153202ea2, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912923, encodeId=c632912923dc, content=<a href='/topic/show?id=38c16204546' target=_blank style='color:#2F92EE;'>#样条回归#</a>进行趋势分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62045, encryptionId=38c16204546, topicName=样条回归)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jan 01 19:06:26 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031333, encodeId=7aa4103133383, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jan 01 16:09:27 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912882, encodeId=67ae91288235, content=肥胖与房颤发生风险增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=41775447713, createdName=ms6000001359986420, createdTime=Fri Jan 01 14:56:19 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
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    2021-01-01 lovetcm

    #样条回归#进行趋势分析

    0

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    2021-01-01 心介

    房颤,临床上碰到很多哦

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=913733, encodeId=dd13913e33ce, content=<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a>,胖了哪里都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Jan 04 22:17:13 CST 2021, time=2021-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268385, encodeId=fb6612683856f, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532027, encodeId=6e26153202ea2, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Sun Jan 03 04:09:27 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912923, encodeId=c632912923dc, content=<a href='/topic/show?id=38c16204546' target=_blank style='color:#2F92EE;'>#样条回归#</a>进行趋势分析, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62045, encryptionId=38c16204546, topicName=样条回归)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jan 01 19:06:26 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031333, encodeId=7aa4103133383, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Jan 01 16:09:27 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912882, encodeId=67ae91288235, content=肥胖与房颤发生风险增加有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=41775447713, createdName=ms6000001359986420, createdTime=Fri Jan 01 14:56:19 CST 2021, time=2021-01-01, status=1, ipAttribution=)]
    2021-01-01 ms6000001359986420

    肥胖与房颤发生风险增加有关

    0

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