Eur Urol:胰岛素血症和炎症性饮食模式与前列腺癌的风险

2021-01-30 AlexYang MedSci原创

高胰岛素血症和炎症是相互关联的途径,将饮食与一些慢性疾病的风险联系起来。有证据表明,这些途径也可能增加了前列腺癌的风险。最近,有研究人员确定了高胰岛素血症饮食和炎症饮食是否与前列腺癌的发病率和死亡率相

高胰岛素血症和炎症是相互关联的途径,将饮食与一些慢性疾病的风险联系起来。有证据表明,这些途径也可能增加了前列腺癌的风险。最近,有研究人员确定了高胰岛素血症饮食和炎症饮食是否与前列腺癌的发病率和死亡率相关

研究人员前瞻性地随访了41209名男性(1986-2014)。在28年的随访中,共记录了5929例前列腺癌病例,包括1019个晚期病例和667个死亡病例。在多变量调整模型中,高胰岛素血症饮食每增加一个标准差(SD),晚期前列腺癌的风险增加7%(HR:1.07;95%CI:1.01-1.15),致命性前列腺癌的风险增加9%(HR:1.09;95%CI:1.00-1.18)。当按年龄分层时,高胰岛素血症饮食仅与早发的侵袭性前列腺癌(65岁以下男性)相关,晚期的每SD的HR为1.20(95%CI:1.06-1.35),致命的为1.22(1.04-1.42),致死的为1.20(1.04-1.38)。在整个研究人群中,炎症饮食与前列腺癌风险无关,但与早期致死性前列腺癌相关(每SD增加的HR:1.16;95%CI:1.00-1.35)。

最后,研究人员指出,高胰岛素血症和炎症可能是饮食模式与侵袭性前列腺癌风险,特别是早发疾病风险之间的潜在机制

原始出处:

Benjamin C Fu, Fred K Tabung, Claire H Pernar et al. Insulinemic and Inflammatory Dietary Patterns and Risk of Prostate Cancer. Eur Urol. Jan 2021

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    2021-03-29 baoya
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    2021-01-30 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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