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实锤！哈佛大学团队全新发现：按摩不仅放松身体，还能促进肌损伤修复！

2021-10-20 网络 网络

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按摩，又称为“马杀鸡”massage，涵盖中式推拿、泰式精油spa、日式指压、巴厘岛式按摩、印度草药按摩、热石按摩等，作为一种缓解肌肉酸痛和损伤的手段，已经有3000年的历史了

按摩，又称为“马杀鸡”massage，涵盖中式推拿、泰式精油spa、日式指压、巴厘岛式按摩、印度草药按摩、热石按摩等，作为一种缓解肌肉酸痛和损伤的手段，已经有3000年的历史了。人们通过各式各样的按摩来放松身心，活动强度大的运动员也常常借助筋膜枪来使肌肉恢复。
 
然而，按摩促进肌肉修复，究竟是心理作用，还是确有其事，一直是一个未解之谜。近日，来自美国哈佛大学团队的一项研究，证明按摩能够快速清除严重损伤肌肉组织内的中性粒细胞，降低肌肉组织内炎症因子水平，促进肌纤维再生。
 
图片
工欲善其事必先利其器，研究团队专门设计了一款小型按摩仪器，能够精确控制按摩的力度和频率，并配有超声可以实时显示肌肉组织应变情况。
 
图片
研究人员发现，肌肉组织严重损伤的小鼠经过14天的按摩治疗后，与对照组相比，按摩组小鼠的肌肉间质纤维化程度明显降低，受损肌纤维数量更少，并且肌肉横截面显示肌纤维更粗，肌肉力量更强，这些结果表明，按摩确实能够促进肌肉损伤修复。
 
然而，在分子层面上，按摩究竟给损伤肌肉造成了怎样的影响还不清楚。
 
我们知道，肌肉损伤后，肌纤维结构破坏，发生变性坏死，同时释放炎症因子和趋化因子，吸引免疫细胞进入损伤部位。免疫细胞一方面吞噬坏死细胞和细胞碎片，另一方面可以分泌因子，促进肌肉前体细胞增殖。
 
那么，是不是按摩改变了损伤肌肉组织的炎症反应呢？
 
为了解答这个疑问，研究人员比较了按摩组和对照组受损肌肉部位的炎症因子水平和免疫细胞构成。
 
结果发现，和对照组相比，在肌肉损伤后第三天，按摩组炎症因子发生明显下降，且大幅下降的炎症因子主要和中性粒细胞趋化、迁移相关，同时，在免疫细胞的组成方面，按摩组肌肉组织内中性粒细胞数量大大减少，而其余免疫细胞则没有明显差异。
 
图片
                                                    图注：损伤肌肉组织经过3天按摩后（上），和对照组（下）相比，中性粒细胞（粉色荧光）明显减少
 
作为对照，研究人员又在小鼠肌肉损伤第三天注射抗Ly6g抗体，清除损伤肌肉中的中性粒细胞，得到了和按摩相似的治疗效果——肌肉修复再生明显加强，侧面证明了中性粒细胞降低是按摩促进肌肉修复的关键。
 
那么，在肌肉修复中，中性粒细胞究竟发挥什么样的作用呢？
 
在体外实验中，研究人员将新鲜提取的肌肉前体细胞（MPCs，能够分化为各类肌肉细胞）与中性粒细胞分泌因子共培养，发现中性粒细胞分泌因子能够促进MPCs增殖。
 
有趣的是，本研究却发现持续地暴露于中性粒细胞因子的环境中，会显著降低MPCs分化，抑制肌生成。
 
由此可以得出，尽管中性粒细胞在肌肉修复前期能够清除损伤细胞、促进肌肉前体细胞增殖，然而，中性粒细胞长期存在，则不利于肌肉前体细胞进一步分化成为成熟的肌纤维。因此，在肌肉损伤后，按摩挤压及时清除损伤部位免疫细胞和炎症因子，对肌肉修复再生至关重要。
 
虽然按摩的发展源远流长，直到近几十年，人们才逐渐接受物理治疗能够影响细胞和组织功能。本项研究揭示了“按摩调节局部炎症反应，促进肌肉修复再生”的原理，首次将“物理治疗”与“免疫疗法”联系在一起，通过一种不需要药物、无创的方式调节机体免疫系统。
 
未来，将会涌现更多物理治疗手段帮助加快肌肉组织甚至其他组织的损伤修复，改善慢性炎症性疾病，并且因为其便捷无创的特点，能够迅速进入临床，真正造福患者。
 
下次肌肉劳损，知道应该怎么办了吧？但一定要是正规场所，还需要专业手法哦！
撰文 | 四五七
编辑 | Jennie

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    2022-06-28 vera_1203

    #新发现#

    0

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    2022-03-22 12498d2fm51(暂无昵称)

    #损伤修复#

    0

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    2022-01-19 ms3000000138974946

    学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1921327, encodeId=f448192132edb, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Tue Jun 28 00:41:30 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083033, encodeId=c20d20830337e, content=<a href='/topic/show?id=1260565460c' target=_blank style='color:#2F92EE;'>#损伤修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56546, encryptionId=1260565460c, topicName=损伤修复)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Tue Mar 22 23:41:30 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185970, encodeId=dbfe11859e0ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75721583, createdName=ms3000000138974946, createdTime=Wed Jan 19 11:42:33 CST 2022, time=2022-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398218, encodeId=9f111398218d8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557536, encodeId=1f30155e5366a, content=<a href='/topic/show?id=7bec398e2e6' target=_blank style='color:#2F92EE;'>#哈佛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39872, encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062220, encodeId=e64d1062220da, content=谢谢老师的指导，学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Wed Oct 20 10:55:02 CST 2021, time=2021-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062217, encodeId=305d106221eae, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/20d73b79cf4a47b8a2e66463f7ac7110/c6f4536917f647e4aa68a1f19b95b818.jpg, createdBy=37075418409, createdName=rainlight, createdTime=Wed Oct 20 10:44:32 CST 2021, time=2021-10-20, status=1, ipAttribution=)]
    2021-10-22 ms3046638856685384

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1921327, encodeId=f448192132edb, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Tue Jun 28 00:41:30 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083033, encodeId=c20d20830337e, content=<a href='/topic/show?id=1260565460c' target=_blank style='color:#2F92EE;'>#损伤修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56546, encryptionId=1260565460c, topicName=损伤修复)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Tue Mar 22 23:41:30 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185970, encodeId=dbfe11859e0ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75721583, createdName=ms3000000138974946, createdTime=Wed Jan 19 11:42:33 CST 2022, time=2022-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398218, encodeId=9f111398218d8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557536, encodeId=1f30155e5366a, content=<a href='/topic/show?id=7bec398e2e6' target=_blank style='color:#2F92EE;'>#哈佛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39872, encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062220, encodeId=e64d1062220da, content=谢谢老师的指导，学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Wed Oct 20 10:55:02 CST 2021, time=2021-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062217, encodeId=305d106221eae, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/20d73b79cf4a47b8a2e66463f7ac7110/c6f4536917f647e4aa68a1f19b95b818.jpg, createdBy=37075418409, createdName=rainlight, createdTime=Wed Oct 20 10:44:32 CST 2021, time=2021-10-20, status=1, ipAttribution=)]
    2021-10-22 amyloid

    #哈佛#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1921327, encodeId=f448192132edb, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Tue Jun 28 00:41:30 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083033, encodeId=c20d20830337e, content=<a href='/topic/show?id=1260565460c' target=_blank style='color:#2F92EE;'>#损伤修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56546, encryptionId=1260565460c, topicName=损伤修复)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Tue Mar 22 23:41:30 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185970, encodeId=dbfe11859e0ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75721583, createdName=ms3000000138974946, createdTime=Wed Jan 19 11:42:33 CST 2022, time=2022-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398218, encodeId=9f111398218d8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557536, encodeId=1f30155e5366a, content=<a href='/topic/show?id=7bec398e2e6' target=_blank style='color:#2F92EE;'>#哈佛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39872, encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062220, encodeId=e64d1062220da, content=谢谢老师的指导，学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Wed Oct 20 10:55:02 CST 2021, time=2021-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062217, encodeId=305d106221eae, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/20d73b79cf4a47b8a2e66463f7ac7110/c6f4536917f647e4aa68a1f19b95b818.jpg, createdBy=37075418409, createdName=rainlight, createdTime=Wed Oct 20 10:44:32 CST 2021, time=2021-10-20, status=1, ipAttribution=)]
    2021-10-20 1436749007

    谢谢老师的指导，学到了很多

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1921327, encodeId=f448192132edb, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Tue Jun 28 00:41:30 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083033, encodeId=c20d20830337e, content=<a href='/topic/show?id=1260565460c' target=_blank style='color:#2F92EE;'>#损伤修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56546, encryptionId=1260565460c, topicName=损伤修复)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Tue Mar 22 23:41:30 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185970, encodeId=dbfe11859e0ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75721583, createdName=ms3000000138974946, createdTime=Wed Jan 19 11:42:33 CST 2022, time=2022-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398218, encodeId=9f111398218d8, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1557536, encodeId=1f30155e5366a, content=<a href='/topic/show?id=7bec398e2e6' target=_blank style='color:#2F92EE;'>#哈佛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39872, encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Fri Oct 22 00:41:30 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062220, encodeId=e64d1062220da, content=谢谢老师的指导，学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5b3006368, createdName=1436749007, createdTime=Wed Oct 20 10:55:02 CST 2021, time=2021-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062217, encodeId=305d106221eae, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210416/20d73b79cf4a47b8a2e66463f7ac7110/c6f4536917f647e4aa68a1f19b95b818.jpg, createdBy=37075418409, createdName=rainlight, createdTime=Wed Oct 20 10:44:32 CST 2021, time=2021-10-20, status=1, ipAttribution=)]
    2021-10-20 rainlight

    学习

    0