Oral Dis:研究确定与儿童肿瘤患者口腔黏膜炎发生的相关风险因素

2022-06-21 sunshine MedSci原创

癌症是导致儿童死亡的第二大病因,主要治疗方式包括手术、放射治疗(RT)和/或化学治疗(CT)。尽管CT是治疗癌症的一种广泛使用和有效的方法,但它对所有快速分裂的细胞,如口腔粘膜细胞,具有很强的毒性。

癌症是导致儿童死亡的第二大病因,主要治疗方式包括手术、放射治疗(RT)和/或化学治疗(CT)。尽管CT是治疗癌症的一种广泛使用和有效的方法,但它对所有快速分裂的细胞,如口腔粘膜细胞,具有很强的毒性。口腔粘膜炎(OM)是肿瘤患者治疗时常出现的一种急性毒性事件。但是,并不是所有的患者都会发展成OM,因此确定能够预测这种情况的关键风险因素至关重要,可为临床医生设计个性化疗法提供信息。近日,发表于Oral Dis的一项系统回顾和荟萃分析旨在确定与儿童癌症患者发生OM相关的潜在风险因素。

研究人员检索了四个电子数据库(MEDLINE/PubMed,EMBASE,Web of Science和Scopus)以确定分析儿科癌症患者OM风险因素的研究。此外,还在纳入的研究的参考文献列表中进行了人工检索,以便找到可能未被识别的研究。

结果,研究共纳入19篇文章。OM的发生率从20%到80.4%不等。在8项(42%)研究中,化疗药物是OM的潜在风险因素。8项(42%)研究还考虑了血液学、肝脏和肾脏参数,而5项(26.3%)研究报告了具体的个体因素。基线疾病、口腔微生物群、基因谱和生物标志物分别在4项(21.5%)研究中报告。荟萃分析结果显示,因OM而接受高风险化疗的群体,其OM的风险增加了2.79倍。

综上所述,该研究结果表明,识别OM的风险因素是至关重要的,以便进行个体化和早期预防治疗。

原始出处:

Amanda de Farias Gabriel, et al., Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta-analysis. Oral Dis. 2022 May;28(4):1068-1084. doi: 10.1111/odi.13863.  

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    2023-02-04 小几洁
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    2022-06-21 ms5000000518166734

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