JAHA:颈动脉硬度与吸烟者的认知功能降低相关

2020-04-27 MedSci原创 MedSci原创

重度吸烟者在神经心理学评估上的表现比同龄人差。然而,传统的肺通气受限和低氧血症的测量只能解释少量的认知差异。本研究的目标是确定在吸烟量和肺功能的影响之外,颈动脉僵硬是否与吸烟者的认知有关。

重度吸烟者在神经心理学评估上的表现比同龄人差。然而,传统的肺通气受限和低氧血症的测量只能解释少量的认知差异。本研究的目标是确定在吸烟量和肺功能的影响之外,颈动脉僵硬是否与吸烟者的认知有关。

本研究纳入分析了84名有重度吸烟史的患者:其中30名无慢性阻塞性肺疾病,31名患有轻中度慢性阻塞性肺疾病,23名患有重度慢性阻塞性肺疾病。参与者完成了问卷调查、肺活量测定、颈动脉超声检查和神经心理学测试。在完全调整的模型中,较高的颈动脉β硬度指数与执行功能处理速度的降低相关(P=0.001)。男性和气流限制也与执行功能处理速度的降低相关。另外,β-硬度指数与其他认知领域的表现无明显相关性。

研究结果显示,颈动脉僵硬与前吸烟者执行功能处理速度的不良表现相关,并超过了年龄、过去吸烟量、气流限制严重程度和低氧血症的影响。

原始出处:

Karin F et al.Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease.JAHA.2020 Apr.

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    2021-03-14 howi
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    2020-04-29 一叶知秋
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