J Endod:成熟恒牙牙髓切断术的长期疗效观察

2020-01-24 lishiting MedSci原创

成熟恒牙因龋暴露后实施的牙髓切断术能够保存剩余牙髓组织,但牙髓和修复的长期效果还未可知。这篇前瞻性研究的目的是为了检测牙髓和修复后牙齿的即刻及长期状态,并检验早期和晚期失败的牙齿在实施治疗时是无症状的还是仅有轻微症状时可能存在的潜在指征。

成熟恒牙因龋暴露后实施的牙髓切断术能够保存剩余牙髓组织,但牙髓和修复的长期效果还未可知。这篇前瞻性研究的目的是为了检测牙髓和修复后牙齿的即刻及长期状态,并检验早期和晚期失败的牙齿在实施治疗时是无症状的还是仅有轻微症状时可能存在的潜在指征。

研究在无菌操作下实施牙髓切断术,并在局部麻醉下通过硅酸三钙类水门汀进行盖髓。评估牙齿5年的牙髓和根尖征兆和症状、修复体的边缘完整性和牙周健康。

结果显示,研究共纳入了52名患者(61 teeth),平均年龄为40岁(range, 21-75 years);17 (32.7%)名男性和35 (67.3%)名女性接受治疗并进行随访。牙髓整体存活率为90.2% (95% confidence interval, 79.8%-96.3%),6颗牙齿虽然修复体完整,但发展为不可逆性牙髓炎和牙髓坏死。术前疼痛是早期治疗失败的潜在指征(P < .05)。术后2至4年存在11例治疗晚期失败的病例:1颗冠方修复完整的牙齿表现为牙髓坏死和无症状慢性根尖周炎,4颗牙齿因继发龋导致无症状根尖周炎,4颗牙髓依旧有活力但需要重新冠方修复,1颗无法修复以及1颗因牙周原因而拔除。最终的修复类型为晚期治疗失败的一个潜在指征(P < .05)。

结论:因龋露髓的无症状发育成熟恒牙可以通过硅酸三钙实施牙髓切断术从而得到有效处理。短期治疗失败的数量较少,可进一步通过牙髓摘除术进行处理。适宜的冠方修复对于维持长期疗效十分重要。

原始出处:

Tan SY, Yu VSH, et al. Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. J Endod. 2020 Jan 2. pii: S0099-2399(19)30914-8. doi: 10.1016/j.joen.2019.11.009.

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    2020-01-26 zhaozuguo
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    2020-01-24 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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到目前为止,少有关于RetroMTA (BioMTA, Seoul, Korea)直接应用于活髓治疗后对牙髓影响的研究。这篇研究的目的是为了比较RetroMTA与ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK)应用于部分牙髓切断术的疗效。

J Endod:葡萄糖载体2和4在MTA牙髓切断术牙髓愈合过程中的作用

盖髓材料促进牙髓形成一薄层的修复性牙本质而使受损牙髓得以愈合。这一过程需要葡萄糖促使损伤区域愈合。葡萄糖通过葡萄糖载体(Glut) 2和Glut4转运,它们是一种跨膜蛋白,充当着守卫的作用。研究推测:葡萄糖通过Glut2/Glut4的转运可能有助于损伤后愈合过程中牙本质桥的形成。因此,这篇研究的目的是为了评估MTA盖髓后在修复性牙本质形成过程中Glut2和Glut4的表达情况。

J Endod:使用TheraCal进行部分牙髓切断术后牙髓的反应:一项临床试验

对于含树脂的充填材料如TheraCal直接作用于牙髓的效力一直存有疑问。这篇研究的目的是为了评估应用TheraCal进行部分牙髓切断术的临床效力,并与Biodentine和ProRoot MTA相比较。

J Endod:自体来源的骨髓间质干细胞对狗牙部分活髓切断术愈合能力的影响

牙髓切断术是因龋和外伤暴露特别是年轻恒牙的一种极其重要的治疗方法。对于部分牙髓切断术的牙齿来说,细胞疗法被认为是牙髓牙本质复合体再生的一种极具希望的方法。这篇研究的目的是为了评估自体来源的骨髓间质干细胞(BMSCs)对行牙髓切断术的狗牙模型愈合能力的影响。