BMJ Open:孕期控制体重可降低妊娠期高血压/妊娠糖尿病的发病风险

2017-01-04 MedSci MedSci原创

本研究旨在探究妊娠期血脂升高与妊娠期高血压(HDP)和妊娠期糖尿病(GDM)之间的联系.采用前瞻性队列研究设计,从2014年2月到11月在中国上海一家三级妇幼医院进行此项研究,共纳入了1310位符合条件的女性,对其孕早期(10-13+周)、中期(22-28周)、晚期(30-35周)甘油三脂(TGs),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-c),高密度脂蛋白胆固醇(HDL-c)进行了连续测定

本研究旨在探究妊娠期血脂升高与妊娠期高血压(HDP)和妊娠期糖尿病(GDM)之间的联系.

采用前瞻性队列研究设计,从2014年2月到11月在中国上海一家三级妇幼医院进行此项研究,共纳入了1310位符合条件的女性,对其孕早期(10-13+周)、中期(22-28周)、晚期(30-35周)甘油三脂(TGs),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-c),高密度脂蛋白胆固醇(HDL-c)进行了连续测定,并分析血脂和HDP和/或GDM结果之间的关系。

结果,和正常组相比,HDP/GDM组孕妇三个阶段的TG浓度均较高(p<0.001),TC 和 LDL-c的数量仅在早期较高(p<0.05)。三组HDL-c 水平相似。和中等TG水平(25-75百分位数)相比,高TG(>75百分位数)数量与HDP/GDM风险增加相关,每个阶段的OR(95%CI)分别是2.04(1.41-2.95),1.81 (1.25 - 2.63) 和1.78 (1.24 -2.54)。从早期到晚期高TG升高(>75百分位数)和HDP风险增高相关,OR是2.09(1.16-3.78)。在28周前高TG升高与GDM风险增加相关,OR是1.67(1.10-2.54)。TG升高与孕期体重增加成正相关(R=0.089, p=0.005)。

总而言之,该研究发现孕期控制体重增加可以降低TG升高,降低HDP/GDM的风险。TGs可以作为复杂妊娠的随访参数,但其他脂质水平只有在前三个月才有意义。        

原始出处:

Hong Shen, Xiaohua Liu, et al.,Associations of lipid levels during gestation with hypertensive disorders of pregnancy and gestational diabetes mellitus: a prospective longitudinal cohort study. BMJ Open 2016;6:e013509.

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    2017-04-13 feather89
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    2017-08-19 gaoxiaoe
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    2017-01-05 susice

    好知识,学习了

    0

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    2017-01-04 xiaotaiyang1

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