Diabetes Care:孕妇妊娠期糖尿病、1型糖尿病和2型糖尿病对子女ADHD风险的影响

2018-10-30 xing.T MedSci原创

由此可见,风险等级表明孕妇糖尿病的严重程度(T1D、T2D与需要抗糖尿病药物的GDM)会影响糖尿病母亲子女患ADHD的风险。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,在这项研究中,研究人员旨在评估孕妇既往存在的1型糖尿病(T1D)、既往存在的2型糖尿病(T2D)和妊娠期糖尿病(GDM)对后代注意力缺陷/多动障碍(ADHD)风险的相对重要性。

这项回顾性出生队列研究纳入了1995年至2012年期间在Kaiser Permanente南加州医院出生的333182名单胎儿童。从4岁开始,通过电子病历对儿童进行前瞻性地随访。研究人员使用调整了潜在混杂因素的Cox回归计算的风险比(HRs)来估计与宫内糖尿病暴露相关的ADHD的相对风险。对于GDM,通过诊断时的孕龄评估暴露时间,并通过妊娠期间抗糖尿病药物治疗的需要评估严重程度。

该研究共有37878名(11.4%)儿童暴露于糖尿病(522名暴露于T1D,7822名暴露于T2D和29534名暴露于GDM)。在4岁以后随访时间的中位数为4.9年(四分位数间距为2.2-9.6)期间,有17415名(5.2%)儿童被诊断为ADHD。ADHD风险与整体GDM(P=0.50)或GDM诊断时的孕龄无关(P=0.16)。然而,需要抗糖尿病药物治疗的GDM暴露儿童比不需要的儿童风险显著增加(P<0.001)。与未暴露于糖尿病的儿童相比,暴露于T1D的儿童ADHD调整后HR为1.57(95%CI为1.09-2.25),暴露于T2D的儿童为1.43(1.29-1.60),暴露于需要抗糖尿病药物治疗的GDM儿童为1.26(1.14-1.41),对于暴露于不需要药物治疗的GDM儿童为0.93(0.86-1.01)。

由此可见,风险等级表明孕妇糖尿病的严重程度(T1D、T2D与需要抗糖尿病药物的GDM)会影响糖尿病母亲子女患ADHD的风险。

原始出处:

Anny H. Xiang,et al.Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring.Diabetes Care.2018.https://doi.org/10.2337/dc18-0733

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    2018-11-01 lg.zhao
  7. [GetPortalCommentsPageByObjectIdResponse(id=1902153, encodeId=3bda190215345, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Mar 23 14:13:00 CST 2019, time=2019-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760862, encodeId=b58e1e6086207, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Sep 27 01:13:00 CST 2019, time=2019-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638820, encodeId=8a70163882022, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jan 18 13:13:00 CST 2019, time=2019-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251162, encodeId=07161251162f7, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Nov 01 00:13:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253630, encodeId=2d541253630f1, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Thu Nov 01 00:13:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307606, encodeId=e1e2130e606ae, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Thu Nov 01 00:13:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041987, encodeId=7e89104198ecb, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Oct 30 12:13:00 CST 2018, time=2018-10-30, status=1, ipAttribution=)]
    2018-10-30 misszhang

    谢谢MedSci提供最新的资讯

    0

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近日,美国约翰斯·霍普金斯大学的研究人员表示,他们利用心脏成像技术对数十名患有最严重和最危险的血压病症的孕妇进行了研究,结果表明,先兆子痫的病症主要损害心脏在两个收缩期之间放松的能力,使得心脏过度劳累,导致泵血能力变差。相关研究成果发表在《美国心脏病学会杂志》(Journal of the American College of Cardiology)上。