J Endod:术前双氯酚酸钾对有症状不可逆牙髓炎下颌磨牙术后疼痛的影响

2020-06-16 lishiting MedSci原创

这篇预期随机双盲临床试验的目的是为了评估术前单独使用口服剂量的双氯酚酸钾(DFK)对罹患有症状不可逆牙髓炎(SIP)下颌磨牙的患者术后疼痛以及急救镇痛药摄入的影响。

这篇预期随机双盲临床试验的目的是为了评估术前单独使用口服剂量的双氯酚酸钾(DFK)对罹患有症状不可逆牙髓炎(SIP)下颌磨牙的患者术后疼痛以及急救镇痛药摄入的影响。

70名急症患者术前具有中等至重度疼痛,在实施牙髓治疗1h (n=35)前随机给与50mg DFK或安慰剂(PLC)。通过170-mm Heft-Parker visual analogue scale记录治疗后6, 12, 24和48h患者的疼痛水平。同时也记录急救镇痛药摄入的发生率。通过Mann Whitney U, Friedman's检验, Wilcoxon's sign rank和Chi2 (χ2)检验对疗效数据进行统计学分析。显著性水平(α)设置为0.05。

结果显示,70名患者中共有68人进行了分析评估(n=34)。2组术前特征相似(p>0.05)。DFK仅在48h的疼痛发生率以及强度比PLC显著减弱(p<0.05)。未记录到DFK自24h至48h (p<0.05)以及PLC (p>0.05)发生的疼痛显著降低。2组间急救阵痛药物摄入的发生率无显著性差异(p>0.05)。食物摄入的时间、性别和急救阵痛药物的摄入与术后疼痛相关(p<0.05)。

结论:术前单独给与口服剂量的50 mg双氯酚酸钾对于减轻SIP下颌磨牙一次法牙髓治疗术后48h的疼痛具有一定作用。

原始出处:

Amatallah Hussein Al-Rawhani, Shaimaa Ismail Gawdat, et al. Effect of Diclofenac Potassium Premedication on Postendodontic Pain in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Placebo-Controlled Double-Blind Trial. J Endod., 2020 May 26;S0099-2399(20)30342-3. doi: 10.1016/j.joen.2020.05.008.

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2049762, encodeId=79332049e6210, content=<a href='/topic/show?id=a3ef202523f' target=_blank style='color:#2F92EE;'>#下颌磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20252, encryptionId=a3ef202523f, topicName=下颌磨牙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Tue Oct 27 23:35:59 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699822, encodeId=157316998223e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Nov 07 21:35:59 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669858, encodeId=d6df1669858e8, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Apr 09 18:35:59 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496179, encodeId=ba3f14961e906, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576255, encodeId=a7cc15e6255cf, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2049762, encodeId=79332049e6210, content=<a href='/topic/show?id=a3ef202523f' target=_blank style='color:#2F92EE;'>#下颌磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20252, encryptionId=a3ef202523f, topicName=下颌磨牙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Tue Oct 27 23:35:59 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699822, encodeId=157316998223e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Nov 07 21:35:59 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669858, encodeId=d6df1669858e8, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Apr 09 18:35:59 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496179, encodeId=ba3f14961e906, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576255, encodeId=a7cc15e6255cf, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
    2020-11-07 xlysu
  3. [GetPortalCommentsPageByObjectIdResponse(id=2049762, encodeId=79332049e6210, content=<a href='/topic/show?id=a3ef202523f' target=_blank style='color:#2F92EE;'>#下颌磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20252, encryptionId=a3ef202523f, topicName=下颌磨牙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Tue Oct 27 23:35:59 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699822, encodeId=157316998223e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Nov 07 21:35:59 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669858, encodeId=d6df1669858e8, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Apr 09 18:35:59 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496179, encodeId=ba3f14961e906, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576255, encodeId=a7cc15e6255cf, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
    2021-04-09 jxrzshh
  4. [GetPortalCommentsPageByObjectIdResponse(id=2049762, encodeId=79332049e6210, content=<a href='/topic/show?id=a3ef202523f' target=_blank style='color:#2F92EE;'>#下颌磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20252, encryptionId=a3ef202523f, topicName=下颌磨牙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Tue Oct 27 23:35:59 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699822, encodeId=157316998223e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Nov 07 21:35:59 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669858, encodeId=d6df1669858e8, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Apr 09 18:35:59 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496179, encodeId=ba3f14961e906, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576255, encodeId=a7cc15e6255cf, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2049762, encodeId=79332049e6210, content=<a href='/topic/show?id=a3ef202523f' target=_blank style='color:#2F92EE;'>#下颌磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20252, encryptionId=a3ef202523f, topicName=下颌磨牙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Tue Oct 27 23:35:59 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699822, encodeId=157316998223e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Nov 07 21:35:59 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669858, encodeId=d6df1669858e8, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Apr 09 18:35:59 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496179, encodeId=ba3f14961e906, content=<a href='/topic/show?id=ad2c6e6792e' target=_blank style='color:#2F92EE;'>#牙髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67679, encryptionId=ad2c6e6792e, topicName=牙髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc8c9243767, createdName=hb2011ye, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576255, encodeId=a7cc15e6255cf, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Thu Jun 18 11:35:59 CST 2020, time=2020-06-18, status=1, ipAttribution=)]

相关资讯

术后疼痛别发慌,多款麻醉帮你忙

常见药物一、阿片类药物该类药物无器官毒性,无封顶效应,是术后镇痛的常见选择。分类阿片受体激动剂:又分为弱阿片药(二阶梯药)和强阿片药(三阶梯药)。前者包括 可待因、双氢可待因等,用于轻中度疼痛镇痛;后者包括吗啡、芬 太尼、哌替啶、舒芬太尼、羟考酮、氢吗啡酮等,用于中重度疼痛 镇痛。阿片受体部分激动剂:针对不同的阿片受体亚型起到激动或拮抗作用,包括喷他佐辛、丁丙诺啡等,用于中度疼痛的治疗。副作用

J Endod:机械辅助震荡减轻根管治疗的术后疼痛:一项系统性回顾和对随机临床试验的Meta分析

这篇系统性回顾和Meta分析的目的是为了评估机械辅助震荡与针头注射冲洗相比是否能够减轻成年患者根管治疗后的术后疼痛(PP)。

J Endod:粘膜下注射皮质类固醇对不可逆牙髓炎根管治疗后疼痛及生活质量的影响:一项随机临床试验

这篇调查研究的目的是为了评估局部浸润皮质类固醇对不可逆牙髓炎行一次性牙髓治疗后牙齿疼痛及生活治疗(QOL)的影响。

J Endod:患者根管治疗后持续疼痛的3年疗效观察分析

这篇研究的目的是为了评估患者根管治疗(RCT)后6个月存在持续疼痛的长期疗效,并评估不同患者疼痛迁延的特点。

2019 SFAR指南:术后疼痛管理

2019年2月,法国麻醉和重症医学学会(SFAR)更新发布了术后疼痛管理指南,该指南时对2008年版指南的更新,指南主要内容涉及围术期疼痛评估,镇痛检查,术后疼痛药物治疗和术后局部镇痛。

J Endod:术前口服用药对非手术根管治疗后疼痛的效果和安全性

这篇综述的目的是使用Meta分析寻求成人术前口服药物对非手术根管治疗(NSRCT)后减轻疼痛的最大有效性。