丹麦研究:房颤患者胃肠道出血,需警惕肠癌!

2020-02-13 xujing 中国循环杂志

房颤患者常规服用华法林、达比加群、利伐沙班和阿哌沙班等抗凝药物,以防止血栓形成而导致中风。然而,存在胃肠道出血的风险,估计每年约有1%-2%的患者会出血。近日,欧洲心脏杂志上发表的一项丹麦研究称,应用抗凝治疗的房颤患者如果出现胃肠道出血,建议进行肠癌的筛查,不能单纯认为是抗凝药物的原因。该研究发现,与没有胃肠道出血的患者相比,那些发生出血的患者被诊断为肠癌的可能性高出11-24倍。该研究中,发生消

房颤患者常规服用华法林、达比加群、利伐沙班和阿哌沙班等抗凝药物,以防止血栓形成而导致中风。然而,存在肠道出血的风险,估计每年约有1%-2%的患者会出血。

近日,欧洲心脏杂志上发表的一项丹麦研究称,应用抗凝治疗的房颤患者如果出现肠道出血,建议进行肠癌的筛查,不能单纯认为是抗凝药物的原因。



该研究发现,与没有胃肠道出血的患者相比,那些发生出血的患者被诊断为肠癌的可能性高出11-24倍。

该研究中,发生消化道出血的心房颤动患者中,有4%至8%被诊断为肠癌。

研究纳入近125 500名18-100岁的房颤患者。在长达三年的抗凝治疗中,发生2576例下消化道出血,其中140人在发现出血后的一年内诊断为肠癌。

研究数据显示,发生胃肠道出血患者与没有胃肠道出血的患者相比,所有年龄段患者的直肠癌风险比都增加,≤65岁的有出血的患者比同龄无出血的患者检出肠癌的可能性高23倍,>85岁的患者检出肠癌的可能性高出11倍。

研究者称,76-80岁患者出血患者患肠癌的绝对风险最高,研究发现,76-80岁的人群,1年肠癌的绝对风险分别增加7倍。

来源:Peter Vibe Rasmussen, et al, Gastrointestinal bleeding and the risk of colorectal cancer in anticoagulated patients with atrial fibrillation, European Heart Journal, 2019,Published:07 February 2020.

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    2020-02-13 心介

    房颤,临床上碰到很多哦

    0

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