Addict Biol:老年人饮酒过多,增加死亡率

2015-12-28 phylis 译 MedSci原创

研究者设计了这项队列研究确定是否过度饮酒会增加死亡的风险,受试者为年龄70-89的男性。研究者报道了2001-2004年受试者的饮酒史(从不,过去,每天小于2两,每天2-4两,每天4-6两,每天超过6两),并采集受试者血样。研究者确定ADH1B rs1229984中G>A多态性并且从西部澳大利亚数据联动系统提取死亡率的数据。其他研究措施包括年龄,教育,BMI,吸烟史,高血压,糖尿病,慢性呼吸

研究者设计了这项队列研究以确定过度饮酒是否会增加死亡的风险,受试者为年龄70-89的男性。研究者报道了2001-2004年受试者的饮酒史(从不、过去、每天小于2两、每天2-4两、每天4-6两、每天超过6两),并采集受试者血样。

研究者确定ADH1B rs1229984中G>A多态性并且从西部澳大利亚数据联动系统提取死亡率的数据。其他研究措施包括年龄、教育、BMI、吸烟史、高血压、糖尿病、慢性呼吸系统疾病、冠心病及卒中。

在3496名受试者中,225((6.4%))名携带ADH1B rs1229984 G >A基因。基因携带者饮酒量显著少于非携带者。与非饮酒者相比,过去饮酒者的校正死亡HR(MHR)值1.15(95% CI : 0.86,1.55),男性每天≤2两的MHR为0.98(95% CI  :0.76,1.25),每天2-4两的MHR为1.13(95% CI :0.85,1.49),每天4-6两的MHR为1.18(95% CI  :0.81,1.71),每天超过6两的MHR为1.87(95% CI: 1.11,3.12)。MHR相关的ADH1B rs1229984 G多态性为0.68(95% CI:0.54,0.87)。

老年饮酒过多与死亡率增加相关,这种相关性很可能是因果关系。研究者并没有发现轻中度饮酒可降低老年男人的死亡率。有关饮酒的健康信息的可能要考虑这份研究的结果。

原文出处:

Almeida OP1, McCaul K, et al. Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study. Addict Biol. 2015 Dec 8.


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    2016-12-08 sunylz
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    2016-02-10 jeanqiuqiu
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    2015-12-29 不着调的小师兄

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