J Endod:新型硅酸钙类牙髓封闭剂的生物相容性和生物活性潜力:Bio-C Sealer和Sealer Plus BC

2020-08-14 lishiting MedSci原创

Bio-C Sealer (BC)和Sealer Plus BC (SPBC)是全新的准备用于临床的生物陶瓷类牙髓封闭剂。这篇研究的目的是评估BC和SPBC封闭剂在大鼠皮下的生物相容性和生物活性潜力。

Bio-C Sealer (BC)和Sealer Plus BC (SPBC)是全新的准备用于临床的生物陶瓷类牙髓封闭剂。这篇研究的目的是为了评估BC和SPBC封闭剂在大鼠皮下的生物相容性和生物活性潜力,并与AH Plus (AHP)相比较。

研究将材料放入聚乙烯管内,空管作为对照,植入大鼠皮下组织。在术后7, 15, 30和60天,将管与其周围结缔组织取出,评估炎症细胞/ mm2 (IC)和白细胞介素-6 (IL-6)免疫标记的细胞。也进行骨钙素(OC)和von Kossa染色分析。采用ANOVA和Tukey检验对数据进行统计学分析,显著性水平设置为5%。

结果显示,术后7天,SPBC的IC水平较BC低(p <0.05)。AHP的IL-6免疫标记细胞数量更高(p <0.05)。术后15天,与其他材料相比,BC展现出较低的IC和IL-6水平。术后30天,SPBC和AHP展现出更高的IC值(p <0.05)。术后60天,硅酸钙材料的IC和IL-6水平之间未见显著性差异(p>0.05),水平值均明显低于AHP (p <0.05)。材料对von Kossa展现出阳性结构。BC在所有阶段均表现出骨钙素阳性。SPBC在15至60天展现出骨钙素阳性。AH Plus和对照组未检测到骨钙素阳性细胞。

结论:Bio-C和Sealer Plus BC封闭剂表现出较好的生物相容性和生物活性潜力。

原始出处:

Evelin Carine Alves Silva, Mario Tanomaru-Filho, et al. Biocompatibility and bioactive potential of new calcium silicate-based endodontic sealers: Bio-C Sealer and Sealer Plus BC. J Endod., 2020 Jul 16;S0099-2399(20)30498-2. doi: 10.1016/j.joen.2020.07.011.

 

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    2021-06-25 szhvet
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    2021-04-29 jxrzshh
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    2020-09-18 sunylz
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    2020-08-14 ms2000001051330459

    学习了,涨知识了!

    0

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