BMJ:辅助生殖与男性前列腺癌风险

2019-09-26 MedSci MedSci原创

通过辅助生殖技术,特别是胞质内精子注射男性人群的早发性前列腺癌风险增加

近日研究人员比较了辅助生殖与自然受孕男性人群的前列腺癌的风险差异。

1994-2014年期间,瑞典名1181490名男性参与研究,其中体外受精(IVF)20 618例,胞质内精子注射(ICSI)14 882例,自然受孕1 145 990例。研究的主要终点为前列腺癌诊断,根据发病年龄和雄激素剥夺治疗评估疾病程度。

在通过IVF、ICSI和非辅助手段的男性中,分别有77人(0.37%)、63人(0.42%)和3244人(0.28%)被诊断为前列腺癌,发病平均年龄分别为55.9岁、55.1岁和57.1岁。与自然受孕男性相比,通过辅助生殖男性患前列腺癌的风险显著增加(ICSI的风险比1.64;IVF的风险比1.33),患早发性疾病的风险也有增加(55岁之前的前列腺癌诊断,ICSI的危险比为1.86;IVF为1.51)。通过ICSI受孕并发展为前列腺癌男性接受雄激素剥夺治疗风险增加(OR:1.91)。

研究发现,通过辅助生殖技术,特别是胞质内精子注射男性人群的早发性前列腺癌风险增加。

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    2019-12-07 sjq027
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    2019-10-06 gaoxiaoe
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    2019-09-26 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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