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Nat Commun：孤化学感官细胞是牙周炎的免疫哨兵

2020-04-06 MedSci原创 MedSci原创

免疫牙周炎
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孤化学感官细胞（SCCs）是上皮哨兵，它利用苦味Tas2r受体和耦合的味觉转导元件来检测病原菌代谢产物，触发宿主防御，控制感染。在这里，我们报告了SCCs存在于小鼠牙龈结节上皮中，它们表达了几个Tas

孤化学感官细胞（SCCs）是上皮哨兵，它利用苦味Tas2r受体和耦合的味觉转导元件来检测病原菌代谢产物，触发宿主防御，控制感染。在这里，我们报告了SCCs存在于小鼠牙龈结节上皮中，它们表达了几个Tas2rs和味觉转导成分α-gustducin（Gnat3）、TrpM5和Plcβ2。Gnat3-/-小鼠的口腔共生微生物群发生了改变，并加速了自然发生的牙槽骨损失。

 

在结扎诱导的牙周炎中，敲除味觉信号分子或基因缺失的牙龈SCCs(gSCCs)会增加细菌负荷，降低细菌多样性，使微生物群更具致病性，导致牙槽骨丧失更大。使用苦味丹激活gSCCs的局部治疗可上调抗菌肽的表达，并改善野生型小鼠结扎诱导的牙周炎，但在Gnat3-/-小鼠中没有。

 

总之，该研究结果表明，gSCCs可能为治疗牙周炎提供了一个有希望的靶点，通过利用先天免疫调节口腔微生物群来治疗牙周炎。

 

原始出处：

 

Xin Zheng, Marco Tizzano, et al., Gingival solitary chemosensory cells are immune sentinels for periodontitis. Nat Commun. 2019; 10: 4496.

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    2020-10-12 liye789132251

    #Nat#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1884226, encodeId=b5e61884226f2, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Oct 12 07:16:33 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087672, encodeId=8e41208e672b2, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun May 10 19:16:33 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381461, encodeId=15543814615b, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Apr 08 09:40:53 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451217, encodeId=b4fe145121eae, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Apr 07 18:16:33 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381425, encodeId=53d33814256d, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Tue Apr 07 09:21:04 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381389, encodeId=7c1938138969, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ea82329997, createdName=1226a71am04(暂无昵称), createdTime=Mon Apr 06 11:26:56 CST 2020, time=2020-04-06, status=1, ipAttribution=)]
    2020-05-10 liuli5079

    #COMMUN#

    0

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    2020-04-08 一天没事干

    很好的学习机会

    0

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    2020-04-07 医者仁心

    #牙周#

    0

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    2020-04-07 一天没事干

    很好的学习机会

    0

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    2020-04-06 1226a71am04(暂无昵称)

    学习了

    0

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