Am J Rhinol Allergy:鼻一氧化氮和鼻细胞学是否可作为舌下过敏原特异性免疫治疗短期疗效的预测标志物?

2022-01-14 AlexYang MedSci原创

评估了鼻腔一氧化氮(nNO)和鼻腔细胞学这两个标志物是否有助于识别SLIT治疗的早期临床疗效。

呼吸道过敏是由存在于家庭环境(灰尘、霉菌)以及外部环境(花粉)中的过敏原引发的。特异性舌下免疫疗法(SLIT)提供了新的和重要的治疗选择。舌下免疫疗法是免疫疗法的一项重大改进,改变了不同类型免疫球蛋白(Ig)E介导的过敏性疾病临床历史。

目前,SLIT是唯一的药物治疗方法,不仅能缓解年轻患者的症状,还能通过病因机制改变过敏性呼吸道疾病的自然史和预后。当下,很少有关于舌下免疫疗法(SLIT)短期反应的研究

近期,来自意大利的研究人员在《Am J Rhinol Allergy》上发表文章,评估了鼻腔一氧化氮(nNO)和鼻腔细胞学这两个标志物是否有助于识别SLIT治疗的早期临床疗效

研究人员招募了34名6至14岁的儿童,他们均诊断为过敏性鼻炎(AR),并记录了对屋尘螨的过敏性情况。研究人员在开始类过敏原单体片剂免疫治疗的同时,还对AR的常规治疗进行了评估,并在基线(T0)、1(T1)、2(T2)、3(T3)和6个月(T6)后通过调查:

i)视觉模拟量表评分(VAS 1-10);

ii)nNO测量结果;

iii)FeNO测量结果;

iv)鼻腔细胞学;

v)肺活量;

vi)任何常规治疗的评估来研究治疗的效果。

结果发现,整体VAS评估的症状有所改善(T0与T6:47.13 vs. 17.57;P<0.05),nNO有统计学意义的显著减少(1035.2 ± 956.08 vs. 139.2 ± 59.01;P<0.05)。因此,当患者完成6个月的治疗后,治疗效果即可达到显著性。细胞学评估显示,鼻腔嗜酸细胞明显减少(T0 vs. T6:87% vs. 16%;P<0.01)。

此外,在T0时,56%的患者还有中性粒细胞,在T6时减少到8%(P <0.05)。

SLIT治疗后3个月和6个月时的鼻腔细胞学情况

综上所述,他们的数据从临床角度证实了SLIT治疗的有效性,并确定了两个生物标志物-nNO和鼻腔细胞学,其可在治疗开始后短期内预测治疗效果。

 

原始出处:

Giuseppe Fabio Parisi , Sara Manti , Maria Papale et al. Nasal Nitric Oxide and Nasal Cytology as Predictive Markers of Short-Term Sublingual Allergen-Specific Immunotherapy Efficacy in Children with Allergic Rhinitis. Am J Rhinol Allergy. Dec 2021.

 

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    2022-01-15 膀胱癌
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    2022-01-14 yangchou

    好文章,值得一读。

    0

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