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Blood：piRNA-30473通过调节m6A RNA甲基化促进DLBCL发生和预后不良

2020-09-25 Q MedSci原创

弥漫性大B细胞淋巴瘤（DLBCL）piRNA-30473m6A RNA甲基化m6A修饰
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iRNA-30473是通过上调m6A mRNA甲基化酶WTAP，从而提高整体m6A水平来发挥其致癌作用。WTAP通过提高其关键靶基因HK2的m6A水平而增加其HK2的表达，从而促进DLBCL的进展。

弥漫性大B细胞淋巴瘤(DLBCL)的发生和发展受遗传和表观遗传异常的调控。作为最丰富的真核信息RNA修饰，N6-甲基腺苷(M6A)通过调控靶基因影响多种基本的生物过程，但M6A修饰在DLBCL中的作用尚不清楚。

PIWI互作RNA(piRNAs)已被认为是癌症的表观遗传效应因子。在该研究中，研究人员发现pIRNA-30473高表达支持了DLBCL的侵袭性表型，且piRNA-30473缺失可减少DLBCL细胞的增殖并诱导细胞周期停滞。

在异种移植DLBCL模型中，抑制piRNA-30473可减慢肿瘤生长。此外，在单因素分析中，piRNA-30473与总生存率(OS)显著相关；在多因素分析中，该相关性经国家综合癌症网络-国际预后指数(NCCN-IPI)校正后仍具有统计学意义。

更多的研究表明，piRNA-30473是通过上调m6A mRNA甲基化酶WTAP，从而提高整体m6A水平来发挥其致癌作用。结合转录组和m6A-seq分析表明，WTAP通过提高其关键靶基因HK2的m6A水平而增加其HK2的表达，从而促进DLBCL的进展。

综上所述，piRNA-30473/WTAP/HK2轴通过调节m6A RNA甲基化而参与DLBCL的发生。此外，通过综合分析该研究的临床数据和数据集，研究人员发现m6A调控基因piRNA-30473和WTAP可改善DLBCL患者的生存预测。

总之，该研究强调了m6A修饰在DLBCL中的功能重要性，并可能有助于发展DLBCL的预后分层和治疗方法。

原始出处：

Huiying Han, et al. piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL. Blood. September 23, 2020.

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    2021-08-25 ms7258648636991762

    #LBCL#

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    2021-06-11 hxzhang

    #piRNA#

    0

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    2020-11-14 kcb077

    #m6A#

    0

  4. 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    2020-10-07 ms6000001392980331

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2021251, encodeId=63432021251a6, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Wed Aug 25 22:59:28 CST 2021, time=2021-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789089, encodeId=a5b41e89089e6, content=<a href='/topic/show?id=945214301d9' target=_blank style='color:#2F92EE;'>#piRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, 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    2020-09-27 ms7000000042545438

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2021251, encodeId=63432021251a6, content=<a href='/topic/show?id=a80f10e3046' target=_blank style='color:#2F92EE;'>#LBCL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10730, encryptionId=a80f10e3046, topicName=LBCL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Wed Aug 25 22:59:28 CST 2021, time=2021-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789089, encodeId=a5b41e89089e6, content=<a href='/topic/show?id=945214301d9' target=_blank style='color:#2F92EE;'>#piRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48315397608, createdName=ms7000000178049994, createdTime=Fri Sep 25 10:10:58 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888185, encodeId=e915888185ae, content=<a href='/topic/show?id=567650039e9' target=_blank style='color:#2F92EE;'>#弥漫大B细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50039, encryptionId=567650039e9, topicName=弥漫大B细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Fri Sep 25 10:06:51 CST 2020, time=2020-09-25, status=1, ipAttribution=), 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    2020-09-27 cathymary

    #DLBCL#

    0

  7. 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    2020-09-27 caoliehu

    #预后不良#

    0

  8. 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    2020-09-25 ms7000000178049994

    果然学无止境，受教了

    0

  9. 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    2020-09-25 Nebula-Qin

    #弥漫大B细胞淋巴瘤#

    0

  10. 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    2020-09-25 内科

    学习

    0

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