Nutrition:补充益生菌和益生元对成年糖尿病患者肠道微生物群的影响

2021-07-31 MedSci原创 MedSci原创

肠道微生物群中16S rRNA基因分析表明,与健康人群相比,肥胖和糖尿病患者的厚壁菌门-拟杆菌门及比例更高。因此,看来通过益生菌/预生菌/合成菌对肠道微生物生态的调控可能有助于代谢性疾病的进展和预防。

肠道微生物群中16S rRNA基因分析表明,与健康人群相比,肥胖和糖尿病患者的厚壁菌门-拟杆菌门及比例更高。因此,看来通过益生菌/预生菌/合成菌对肠道微生物生态的调控可能有助于代谢性疾病的进展和预防。一项随机、双盲、安慰剂对照的临床试验评估了益生菌和益生菌补充对成人糖尿病前期患者的肠道微生物组的改变的影响,研究结果已发表于Nutrition。

研究共纳入了120名糖尿病前期患者,随机分配到每天食用6克含有麦芽糊精的安慰剂(对照)或多菌种益生菌或基于菊粉的益生菌6个月。基线和6个月后获得粪便样本。在整个研究过程中(基线和3个月和6个月后)对饮食摄入进行评估。计算总能量、宏量营养素和膳食纤维。从粪便样本中提取DNA,通过实时定量聚合酶链反应(qPCR)确定梭状芽孢杆菌(代表韧皮菌门)、脆弱杆菌(代表类杆菌门)和大肠杆菌(作为通用细菌)的数量。分析了两种粪便细菌的相对丰度在补充营养前后的变化,并在组内和组间进行了比较。

 

结果,在研究期间,饮食摄入量没有明显变化。补充益生菌6个月后,脆弱杆菌对大肠杆菌的丰度显著增加(平均差异[MD] ± SE 0.47 ± 0.37,P = 0.04),类杆菌对类杆菌代表的相对比例降低(MD ± SE -118.8 ± 114.6,P = 0.02)。Synbiotic对细菌的变化没有明显影响。三组之间没有显著差异。

综上,本研究结果表明,通过使用益生菌操纵人类肠道微生物组可以为预防和管理肥胖症和代谢性疾病(如糖尿病)提供一种潜在的治疗方法。

 

原始出处:

 

Nazila Kassaian, et al., The effects of 6 mo of supplementation with probiotics and synbiotics on gut microbiota in the adults with prediabetes: A double blind randomized clinical trial. Nutrition. Nov-Dec 2020;79-80:110854. doi: 10.1016/j.nut.2020.110854.  

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    2021-08-02 mnda
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    2021-07-31 misszhang

    谢谢MedSci提供最新的资讯

    0

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