J Rheumatol:苯丙氨酸是放射性膝关节骨关节炎进展的新型标志物

2020-05-08 xiangting MedSci原创

苯丙氨酸是女性双侧放射学膝关节OA进展风险升高的新型血浆标志物。

这项研究使用代谢组学的方法,确定与放射性膝关节骨关节炎(OA)进展风险升高相关的血浆标志物。

研究参与者来自多中心骨关节炎研究(MOST),并根据是否存在基线放射性OA将其分为两组。组1的受试者患有单侧膝关节骨关节炎,组2受试者患有双侧膝关节骨关节炎。进展定义为30个月随访时关节间隙宽度恶化≥半度。对于组1,当OA膝关节出现影像学进展和对侧膝关节出现OA时则意味着进展。对于组2,当双膝关节OA出现影像学进展时则意味着进展。对基线采集的血清样品进行代谢组学分析,并在调整年龄、性别、BMI和临床部位后,进行了logistic回归以分析每种代谢物与膝关节OA进展之间的关联。

分析纳入234名进展者(组1为57名,组2为177名)和322名非进展者(组1为206名,组2为116名)。在研究的157种代谢产物中,研究发现在联合分析中,苯丙氨酸水平每升高1标准差(SD),进展的几率升高1.46倍(95%CI:1.20-1.77,p=0.0001)。性别特异性分析表明,女性中苯丙氨酸水平与进展风险有关联(p=0.0002),而男性中没有。

这项研究数据表明,苯丙氨酸是女性双侧放射学膝关节OA进展风险升高的新型血浆标志物。

原始出处:

Guangju Zhai. Phenylalanine is a novel marker for radiographic knee osteoarthritis progression: the MOST study. J Rheumatol. 01 May 2020.

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    2021-03-22 lisa438
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    2020-05-10 lmm397
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