JAMA Intern Med:老年糖尿病前期人群特征及后续糖尿病风险

2021-02-10 MedSci原创 MedSci原创

在老年群体中,糖尿病前期人群的比例较高,但随访期间血糖水平回归正常或死亡的比例高于发展为糖尿病确诊患者的比例

糖尿病前期是指血糖偏高但未达到糖尿病诊断标准的"中间"状态,是糖尿病的早期预警信号。老年人是糖尿病的高风险人群,但对于老年糖尿病前期人群,其特征尚未得到充分研究。近日研究人员比较了不同的糖尿病前期定义条件下,老年糖尿病前期异常率和后续糖尿病风险。
 
研究人员收集社区动脉粥样硬化风险研究(Atherosclerosis Risk in Communities Study,基线2011-13年)中,3412名无糖尿病的老年参与者数据,随访至2016年1月,平均随访期为5.0年,糖尿病前期的定义为糖化血红蛋白(HbA1c)水平为5.7%-6.4%,空腹血糖异常(IFG,FG水平为100-125mg/dl),或两者兼而有之。研究的主要终点为糖尿病确诊(HbA1c≥6.5%或FG≥126 mg/dL)。
 
参与者平均年龄75.6岁,女性占60%,黑人占17%。随访期间,发生156起糖尿病事件,434人死亡。1490名参与者(44%)的HbA1c在5.7-6.4%,1996人IFG(59%),总计2482人符合前期糖尿病定义,1004人同时HbA1c和FG异常(73%)。对于基线HbA1c水平5.7-6.4%的人群,97人发展为糖尿病(9%),148人血糖恢复正常(13%, HbA1c<5.7%),207人死亡(19%)。基线IFG人群,112人(8%)确诊糖尿病、647人空腹血糖恢复正常(44%,FG<100 mg/dL),236人(16%)死亡。对于基线HbA1c水平低于5.7%的人群,239人(17%)HbA1c进展为5.7-6.4%,41人(3%)发展为糖尿病。对于基线FG水平低于100 mg/dL人群,80人(8%)发展为IFG,而26人(3%)发展为糖尿病。
 
研究发现,在老年群体中,糖尿病前期人群的比例较高,但随访期间血糖水平回归正常的比例高于发展为糖尿病确诊患者的比例
 
原始出处:
 
Mary R. Rooney et al. Risk of Progression to Diabetes Among Older Adults With Prediabetes. JAMA Intern Med. February 8, 2021.

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    2021-03-03 ms1000000131779134

    谢谢了

    0

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    2021-02-13 ms3000000728156085

    学习了!

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=945020, encodeId=bfef945020ed, content=谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7275456279, createdName=ms1000000131779134, createdTime=Wed Mar 03 06:55:01 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924420, encodeId=f77c9244200c, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33ac5447033, createdName=ms3000000728156085, createdTime=Sat Feb 13 10:31:47 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479544, encodeId=b86614e9544c7, content=<a href='/topic/show?id=466b8021e01' target=_blank style='color:#2F92EE;'>#老年糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80217, encryptionId=466b8021e01, topicName=老年糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Feb 12 09:08:31 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610893, encodeId=6baf16108931d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 12 09:08:31 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924238, encodeId=d2b89242386c, content=涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Fri Feb 12 07:47:25 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924146, encodeId=523c924146c5, content=积极控制,就可返回正常👦, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Feb 11 06:31:48 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036446, encodeId=b4d3103644646, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Feb 10 21:08:31 CST 2021, time=2021-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043505, encodeId=079e10435059b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Feb 10 21:08:31 CST 2021, time=2021-02-10, status=1, ipAttribution=)]
    2021-02-12 carrotlyl

    涨知识

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=945020, encodeId=bfef945020ed, content=谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7275456279, createdName=ms1000000131779134, createdTime=Wed Mar 03 06:55:01 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924420, encodeId=f77c9244200c, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33ac5447033, createdName=ms3000000728156085, createdTime=Sat Feb 13 10:31:47 CST 2021, time=2021-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479544, encodeId=b86614e9544c7, content=<a href='/topic/show?id=466b8021e01' target=_blank style='color:#2F92EE;'>#老年糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80217, encryptionId=466b8021e01, topicName=老年糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Feb 12 09:08:31 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610893, encodeId=6baf16108931d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Feb 12 09:08:31 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924238, encodeId=d2b89242386c, content=涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Fri Feb 12 07:47:25 CST 2021, time=2021-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924146, encodeId=523c924146c5, content=积极控制,就可返回正常👦, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Feb 11 06:31:48 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036446, encodeId=b4d3103644646, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Feb 10 21:08:31 CST 2021, time=2021-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043505, encodeId=079e10435059b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Feb 10 21:08:31 CST 2021, time=2021-02-10, status=1, ipAttribution=)]
    2021-02-11 学医无涯

    积极控制,就可返回正常👦

    0

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    2021-02-10 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2021-02-10 misszhang

    谢谢MedSci提供最新的资讯

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