Lancet Infect Dis：脊髓灰质炎粘膜免疫研究

2016-09-15 Mechront 译 MedSci原创

对于全球根除脊髓灰质炎目标，识别限制脊髓灰质炎病毒复制的机制是至关重要的。目前通过口服脊髓灰质炎病毒或灭活脊髓灰质炎病毒（IPV）疫苗，以及混合计划下诱导的粘膜免疫(OPV)相关研究将告诉我们不同策略的不同阻断效果。我们对来自临床试验的样本进行了研究，对不同疫苗接种计划下的肠道免疫功能进行评估（通过粪便中的中和病毒和病毒特异性IgA浓度进行评估）。 FIDEC试验中，将拉丁美洲婴儿随机分为九

对于全球根除脊髓灰质炎目标，识别限制脊髓灰质炎病毒复制的机制是至关重要的。目前通过口服脊髓灰质炎病毒或灭活脊髓灰质炎病毒（IPV）疫苗，以及混合计划下诱导的粘膜免疫(OPV)相关研究将告诉我们不同策略的不同阻断效果。我们对来自临床试验的样本进行了研究，对不同疫苗接种计划下的肠道免疫功能进行评估（通过粪便中的中和病毒和病毒特异性IgA浓度进行评估）。

FIDEC试验中，将拉丁美洲婴儿随机分为九组，选择了三组进行分析：二价OPV(bOPV)对照组（6、10、14周；血清型1和3）、三价减毒OPV (tOPV)对照组（6、10、14周）、bOPV–IPV组（bOPV 6、10、14周+IPV 14周）。婴儿18周时，2型单价OPV挑战后，检测粪便中中和活性和脊髓灰质炎病毒型特异性IgA。通过体外测定2型脊髓灰质炎(PV2)的中和情况，评估黏膜免疫。在挑战前和挑战2周后，收集了所有参与者的中和滴度、总的和脊髓灰质炎病毒特异性IgG和IgA浓度。

研究者对来自瓜地马拉和多米尼加共和国的210名婴儿进行分析。tOPV组对38名婴儿进行了黏膜抗体检测，挑战1周后2名婴儿有脱落病毒；bOPV组中的数据则为59/85(p<0·0001)，bOPV–IPV组数据为53/87(p<0·0001)。对tOPV反应过程中，发现了2型中和粘膜和特定类型相关IgA。挑战时，病毒脱落和2型中和血清存在逆相关(p<0·0001)，与2型中和粘膜也是逆相关(p<0·0001)。

结果表明，可以通过粪便检测粘膜2型特异性抗体；这些粘膜抗体会影响既定感染中脱落的病毒量。

原始出处：

Peter F Wright,et al.Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants.Lancet Infect Dis.Online First.DOI: http://dx.doi.org/10.1016/S1473-3099(16)30169-4

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2017-03-07 guoyibin

#粘膜#

24 0
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2016-11-15 cmj8wellington

#Dis#

34 0
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2017-04-29 howi

#Lancet#

23 0
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2016-10-11 1e10c84am36(暂无匿称)

好文章，受益

54 0
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2016-09-16 12498c32m70暂无昵称

#脊髓灰质炎#

0 0
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level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 20:43:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127998, encodeId=28b612e99889, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 17:34:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), 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2016-09-15 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

50 0
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2016-09-15 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

63 0
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2016-09-15 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

52 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 15:09:22 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483118, encodeId=5518148311827, content=<a href='/topic/show?id=19398461920' target=_blank style='color:#2F92EE;'>#脊髓灰质炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84619, encryptionId=19398461920, topicName=脊髓灰质炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b9117881304, createdName=12498c32m70暂无昵称, createdTime=Fri Sep 16 22:38:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128174, encodeId=d15f1281e4f4, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 20:43:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127998, encodeId=28b612e99889, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 17:34:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), 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createdName=医路开来, createdTime=Thu Sep 15 15:01:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127716, encodeId=dbfd12e716b5, content=学习了，赞一个！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Thu Sep 15 14:59:00 CST 2016, time=2016-09-15, status=1, ipAttribution=)]
2016-09-15 医路开来

学习啦，，，

56 0
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createdName=cmj8wellington, createdTime=Tue Nov 15 05:38:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828630, encodeId=9ab41828630c9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Apr 29 16:38:00 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144421, encodeId=7a7f144421ea, content=好文章，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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2016-09-15 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

29 0

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