Diabetes Care:空腹血糖与COVID-19严重程度的关系

2020-10-14 MedSci原创 MedSci原创

该研究结果表明COVID-19患者入院时应严格控制血糖。FBG在正常范围内,即使很小程度的升高也与COVID-19患者入住ICU风险显著增加有关。

空腹血糖(FBG)可能是2019新型冠状病毒病(COVID-19)发病率和死亡率的独立预测因子。但是,当作为预测变量纳入模型时,通常按线性、二分类或分类方式对其进行建模。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在全面分析FBG建模的不同方法,以评估COVID-19入住重症监护室(ICU)的风险。

研究人员利用科威特COVID-19患者数据,采用传统方法拟合FBG建模,以及采用惩罚样条方法进行非线性估计。

研究人员对于417例患者,采用传统的线性、二分法和分类方法对FBG进行建模时,无法发现暴露-反应关系中的关键趋势。研究人员采用非线性估计得到一个陡峭的斜率,直到变平之前约为10 mmol/L。

由此可见,该研究结果表明COVID-19患者入院时应严格控制血糖。FBG在正常范围内,即使很小程度的升高也与COVID-19患者入住ICU风险显著增加有关。
 
原始出处:
 
Barrak Alahmad,et al.Fasting Blood Glucose and COVID-19 Severity: Nonlinearity Matters.Diabetes care.2020.https://care.diabetesjournals.org/content/early/2020/10/11/dc20-1941

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    2020-10-14 1861e93c24m

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