JCEM:接受减肥手术青少年的骨代谢情况

2020-11-17 MedSci原创 MedSci原创

青少年MBS与aBMD降低有关,并且轴向骨骼的MAT增加,而袖胃切除术与皮质vBMD的增加以及周围骨骼的MAT减少有关。

在过去的几十年中,儿童肥胖症的患病率不断增加,与此同时代谢和减肥手术(MBS)也随之增加。尽管成年人MBS与骨质流失相关,但只有少数研究评估了MBS对青少年骨骼生长的影响。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,这篇小型综述总结了最常用的MBS(袖胃切除术和胃旁路术)对青少年骨骼的影响的可用数据。研究人员使用PubMed对英文文献进行了系统的检索和综述。

所有MBS后,DXA测量的区域骨矿物质密度(aBMD)和BMD Z评分均降低。袖胃切除术后一年,腰椎定量CT(QCT)测定的体量性BMD(vBMD)降低,而桡骨和胫骨的皮质vBMD增加(总vBMD不变)。在这段时间内观察到狭窄的颈部和转子间的横截面积以及皮质厚度降低,并且髋部力量的估计受到了不利影响。袖胃切除术后一年,腰椎的骨髓脂肪组织(MAT)增加,而外周骨骼的MAT减少。体重减轻、瘦肉和脂肪减少与所有部位的骨质流失以及周围部位的骨微结构变化有关。

由此可见,青少年MBS与aBMD降低有关,并且轴向骨骼的MAT增加,而袖胃切除术与皮质vBMD的增加以及周围骨骼的MAT减少有关。

原始出处:

Madhusmita Misra.et al.Bone Metabolism in Adolescents Undergoing Bariatric Surgery.JCEM.2020.https://doi.org/10.1210/clinem/dgaa836

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    2021-08-01 achengzhao
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    2021-04-17 smallant2015
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    2020-11-17 CHANGE

    什么时候有懒人用的减肥神药?

    0

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    2020-11-17 Andy7809

    不错的文章

    0

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    2020-11-17 夜空中的星星

    涨知识啦

    0

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