Nutrients:Omega-3脂肪酸作为营养支持是否可减少烧伤患者的各种并发症、死亡率和住院时间?

2022-08-07 MedSci原创 MedSci原创

烧伤是一个常见的严重健康问题,死亡率很高。越来越多的人认识到烧伤患者的高代谢,伴随着胰岛素抵抗和明显的炎症反应。

烧伤是一个常见的严重健康问题,死亡率很高。越来越多的人认识到烧伤患者的高代谢,伴随着胰岛素抵抗和明显的炎症反应。由于烧伤患者的能量消耗高于正常人,根据烧伤的部位、营养不良的风险或任何其他合并症,营养支持是烧伤治疗过程的一个关键部分。鱼油作为营养支持中Omega-3脂肪酸的主要来源,可以减轻炎症反应并增强免疫功能,然而其对改善烧伤患者的临床结果的影响仍不清楚。近日,发表于Nutrients的一项研究评估了补充Omega-3脂肪酸对烧伤患者结局的影响。

研究人员系统检索了Cochrane图书馆、PubMed、ScienceDirect和Scopus数据库纳入烧伤患者中使用Omega-3脂肪酸作为营养支持与对照饮食的随机对照试验。分析的结果包括Omega-3脂肪酸/鱼油组和对照组之间的总死亡率、机械通气天数、住院时间、感染性并发症(菌血症、肺炎、败血症、尿路感染和伤口感染)和胃肠道并发症(便秘和腹泻)。

 

结果,该项荟萃分析共纳入了7项试验。分析结果显示,接受Omega-3脂肪酸组和对照组/其他饮食组在住院时间(p = 0.59)、死亡率(p = 0.86)、机械通气天数(p = 0.16)、胃肠道并发症--如便秘和腹泻(p = 0.73)或感染性并发症--如肺炎和败血症(p = 0.22)方面没有明显差异。

综上所述,该研究结果表明,目前的研究并不支持Omega-3脂肪酸营养支持对减少烧伤患者的各种并发症、死亡率和住院时间有好处。未来需要进一步的研究,以探究Omega-3脂肪酸的营养支持与低脂肪饮食在烧伤患者人群中的效果。

原始出处:

Tippawan Siritientong, et al., Nutritional Support with Omega-3 Fatty Acids in Burn Patients: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022 Jul 13;14(14):2874. doi: 10.3390/nu14142874.

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    2022-08-13 丁鹏鹏
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