Nat Commun:下丘脑炎症是如何参与糖尿病表型的?

2020-11-23 haibei MedSci原创

在下丘脑中,稳健和经典的炎症激活已被发现可以导致疾病,如厌食症和糜烂。同样,在啮齿动物模型和人类中,下丘脑炎症对于饮食肥胖和相关代谢紊乱的发病机制十分重要。

在下丘脑中,稳健和经典的炎症激活已被发现可以导致疾病,如厌食症和糜烂。同样,在啮齿动物模型和人类中,下丘脑炎症对于饮食肥胖和相关代谢紊乱的发病机制十分重要。

下丘脑炎症最近已被牵连进更大范围的代谢性疾病,从肥胖扩大到2型糖尿病血管疾病,和代谢综合征。多个分子介质或途径已被确定为下丘脑炎症的关键成员,包括营养元素,细胞因子,趋化因子,信号分子,内质网和氧化应激,和自噬失调。

小胶质细胞,星形胶质细胞,血管周围巨噬细胞和神经元是有助于与代谢紊乱相关的下丘脑炎症的关键细胞类型。新出现的证据表明,小胶质细胞和星形胶质细胞在与肥胖和糖尿病相关的下丘脑功能障碍中发挥了关键作用。

 

下丘脑炎症在干扰进食行为和能量平衡,以及肥胖和糖尿病的发病机制中起着重要作用。最近,研究人员在Nature Communications杂志发文,表明丙酮酸脱氢酶激酶(PDK)-2在糖尿病小鼠模型的下丘脑炎症及其后遗症中起着重要作用。

下丘脑星形胶质细胞中PDK2的细胞类型特异性基因消融和药物抑制实验表明,下丘脑星形胶质细胞参与了糖尿病表型。

研究人员还表明,PDK2-乳酸轴在小鼠原代星形胶质细胞和类器官培养物中观察到的代谢失衡和下丘脑炎症中起着调节作用,其通过AMPK信号通路和神经肽电路调节进食行为。

因此,该研究结果揭示了PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。

 

原始出处:

Md Habibur Rahman et al. Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes. Nature Communications (2020). 

 

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    2021-02-18 liye789132251
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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2021-09-16 liuli5079
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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-25 146dbe66m51暂无昵称

    好呀

    0

  4. 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1884808, encodeId=6f2d18848084f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 18 07:39:45 CST 2021, time=2021-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087831, encodeId=2e3b208e83125, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1884808, encodeId=6f2d18848084f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 18 07:39:45 CST 2021, time=2021-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087831, encodeId=2e3b208e83125, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, 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href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Wed Nov 25 01:39:45 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043405, encodeId=c1cc1043405a9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Nov 23 13:39:45 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901435, encodeId=6670901435ee, content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-25 tastas
  7. 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-25 xlwang2696
  8. 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-25 xlwang2696
  9. 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-23 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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content=PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Mon Nov 23 13:34:19 CST 2020, time=2020-11-23, status=1, ipAttribution=)]
    2020-11-23 Oranhyg

    PDK2在小鼠星形胶质细胞中的消融或抑制可减轻糖尿病诱导的下丘脑炎症和随后的进食行为改变。

    0

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