Environ Health:室内微生物气溶胶与五岁以下儿童呼吸道症状的关系:系统性回顾和元分析

2021-07-21 AlexYang MedSci原创

居住的室内环境中的微生物群落,由细菌、真菌和病毒各种微生物组成。人类特别是五岁以下的儿童,90%以上的时间都是在室内中度过的。尽管人们认识到了室内微生物暴露对儿童健康的重要性,但对不同的微生物在呼吸道

居住的室内环境中的微生物群落,由细菌、真菌和病毒各种微生物组成。人类特别是五岁以下的儿童,90%以上的时间都是在室内中度过的。尽管人们认识到了室内微生物暴露对儿童健康的重要性,但对不同的微生物在呼吸道症状和疾病的发展和加重中的作用却知之甚少。近期,有研究人员评估了室内环境中的微生物气溶胶暴露是否与5岁以下儿童的呼吸道症状有关

研究人员在PubMed、Web of Science、GreenFILE、ScienceDirect、EMBASE和Cochrane图书馆进行了系统性的文献检索,直至2020年2月。纳入了那些调查室内微生物群落成分与5岁以下儿童呼吸道症状之间的暴露-反应关系的研究。应用随机效应元分析估计了特定的高与低微生物暴露的合并相对风险(RR)和95%置信区间(CI)。使用留一分析法评估了个别研究对总体估计的潜在影响,异质性则通过RevMan 5.3的I2统计数据进行评估。

共有15项研究符合纳入元分析的条件。合并风险估计表明,微生物暴露的增加与呼吸道症状风险的增加有关[合并的相对风险(RR):1.24(1.09,1.41),P=0.001]。接触曲霉菌、青霉菌、云芝菌和链格孢菌的组合时,这种关联性最强[合并的RR:1.73(1.30,2.31),P=0.0002]。分层分析显示,任何微生物暴露都会增加喘息[合并RR:1.20(1.05,1.37),P=0.007]和过敏性鼻炎[RR:1.18(0.94,1.98),P=0.16]的风险。

IM暴露与呼吸道症状之间关系的评估

综上所述,一般来说,微生物暴露与呼吸道症状的风险有关。未来的研究需要更全面地研究室内微生物组,并调查这些关联的机制

原始出处:

Adekunle Gregory Fakunle , Nkosana Jafta , Rajen N Naidoo et al. Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis. Environ Health. Jul 2021

 

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    2021-07-23 zhmscau
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    2021-07-23 huagfeg
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    2021-07-23 july_979
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