Nat Med:阿维鲁单抗联合阿西替尼与舒尼替尼治疗晚期肾细胞癌:JAVELIN Renal 1013期试验生物标志物分析

2020-09-23 AlexYang MedSci原创

在近期发表在nature medicine期刊的一项研究中来自美国纪念斯隆凯特琳癌症中心的研究人员报告了阿维鲁单抗联合阿西替尼治疗先前未经治疗的肾细胞癌患者的Ⅲ期临床研究(JAVELIN Renal

在近期发表在nature medicine期刊的一项研究中来自美国纪念斯隆凯特琳癌症中心的研究人员报告了阿维鲁单抗联合阿西替尼治疗先前未经治疗的肾细胞癌患者的Ⅲ期临床研究(JAVELIN Renal 101,(n = 886;NCT02684006))的基线肿瘤样本分子分析,结果显示,与舒尼替尼相比,一线阿维鲁单抗联合阿西替尼可显著延长晚期肾细胞癌(aRCC)的无进展生存期(PFS)。

研究人员发现,无论是常用于评估的生物标志物PD-L1的表达还是肿瘤突变总量均不能区分两个研究组的PFS。同样,Fc?R单核苷酸多态性的存在也未能奏效。他们确定了与治疗组间PFS差异相关的重要生物学特征,包括新的免疫调节和血管生成基因表达标志(GESs)、之前未描述的突变谱和相应的GESs,以及几种HLA类型。

蛋白质改变变异对临床结果的影响

这些发现提供了对PD-1/PD-L1和血管生成通路抑制联合反应的决定因素的见解,并可能有助于制定改善aRCC患者护理的策略。

原始出处:

Motzer, R.J., Robbins, P.B., Powles, T. et al. Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial. Nat Med (2020).

 

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    2020-10-05 liye789132251
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    2020-12-14 jml2020
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  5. 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    2020-09-29 ms7000001849897119

    学习了

    0

  6. 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