北京协和医院发现世界首例成人HIV抗体阴性艾滋病合并KS病例

2017-11-28 张思玮 段文利 科学网

近日,记者从北京协和医院获悉,该院呼吸内科、感染内科、病理科联合报道了世界首例成人HIV抗体阴性艾滋病合并肺卡波西肉瘤病例,发表在最新一期的《临床呼吸杂志》(Clinical Respiratory Jounal论文链接)上。

近日,记者从北京协和医院获悉,该院呼吸内科、感染内科、病理科联合报道了世界首例成人HIV抗体阴性艾滋病合并肺卡波西肉瘤病例,发表在最新一期的《临床呼吸杂志》(Clinical Respiratory Jounal论文链接)上。

该患者为中年男性,因咽痛、咯血、发热及呼吸困难两个月,辗转就诊于国内多家医院,症状并未缓解,而后来到协和医院就诊。入院检查发现双肺多发团块样阴影,CD4阳性T淋巴细胞只有6个/mm3(正常人平均760个),HIV初筛试验可疑阳性,但确证试验为阴性。行肺部穿刺活检后,病理科专家在镜下发现了肺部病变是卡波西肉瘤(KS),而该病好发于免疫功能低下人群及艾滋病人。感染内科会诊后,鉴于患者情况,马上为其做了血浆HIV核酸检测,病毒载量高达42969拷贝/毫升。在该患者入院10天后确诊其为HIV抗体阴性艾滋病伴KS。患者虽接受积极的抗感染治疗和针对KS的化疗,终因病情已进展到艾滋病终末期,于确诊两周后死亡。

据专家介绍,KS是HIV/AIDS患者常见的机会性肿瘤,也是HIV/AIDS进展到终末期的一个表现。经文献检索,该患者是在成人中发现的世界首例HIV抗体阴性艾滋病合并肺KS,英国曾报道一例儿童患者。论文第一作者、北京协和医院呼吸内科副教授张弘认为,协和医院率先在国内通过病理确诊肺KS,具有开创性意义,有助于提高国内医生对该病的认识。

论文通信作者、北京协和医院感染内科教授李太生说,本例患者在多地多家医院检测HIV抗体及确证试验均无法明确诊断的情况下,通过核酸检测发现患者体内存在高复制的HIV 病毒,从而确诊为晚期艾滋病,揭示了HIV核酸检测在艾滋病诊断中的重要价值。

那么,有没有必要将核酸检测作为HIV感染的筛查手段呢?李太生说,目前国内HIV抗体检测的第四代试剂盒非常灵敏,已将HIV/AIDS的窗口期由原来的3个月缩短至3周。因技术门槛及成本等问题,核酸检测并不建议作为HIV/AIDS的常规筛查和诊断手段,但对于HIV早期感染但在抗体检查“窗口期”的人、临床上高度怀疑为晚期艾滋病,但抗体检查阴性或者免疫蛋白印迹试验不确定的病例中推荐使用,该建议已由中华医学会感染病分会艾滋病学组写入2015年版《中国艾滋病诊疗指南》。

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    2018-10-06 Homburg
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Tue Nov 28 19:13:47 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265075, encodeId=1da12650e59f, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Nov 28 17:40:07 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265061, encodeId=7dad26506176, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Nov 28 16:22:50 CST 2017, time=2017-11-28, status=1, ipAttribution=)]
    2017-11-28 happsf

    好好学习

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Tue Nov 28 19:13:47 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265075, encodeId=1da12650e59f, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Nov 28 17:40:07 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265061, encodeId=7dad26506176, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Nov 28 16:22:50 CST 2017, time=2017-11-28, status=1, ipAttribution=)]
    2017-11-28 明心见性

    很好.谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2036528, encodeId=51f4203652867, content=<a href='/topic/show?id=8ebe8910d5' target=_blank style='color:#2F92EE;'>#HIV抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8910, encryptionId=8ebe8910d5, topicName=HIV抗体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Sat Oct 06 13:02:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763689, encodeId=71481e636891f, content=<a href='/topic/show?id=2796336294e' target=_blank style='color:#2F92EE;'>#北京协和#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33629, encryptionId=2796336294e, topicName=北京协和)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Nov 28 16:22:50 CST 2017, time=2017-11-28, status=1, ipAttribution=)]
    2017-11-28 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2036528, encodeId=51f4203652867, content=<a href='/topic/show?id=8ebe8910d5' target=_blank style='color:#2F92EE;'>#HIV抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8910, encryptionId=8ebe8910d5, topicName=HIV抗体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Sat Oct 06 13:02:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763689, encodeId=71481e636891f, content=<a href='/topic/show?id=2796336294e' target=_blank style='color:#2F92EE;'>#北京协和#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33629, encryptionId=2796336294e, topicName=北京协和)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Tue Nov 28 19:13:47 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265075, encodeId=1da12650e59f, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Nov 28 17:40:07 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265061, encodeId=7dad26506176, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Nov 28 16:22:50 CST 2017, time=2017-11-28, status=1, ipAttribution=)]
    2017-11-28 惠映实验室

    学习了.谢谢.

    0

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自1981年世界第一例艾滋病(HIV)病毒感染者发现,到现在艾滋病在全球肆虐流行。近几年来,科学家在研究HIV的道路上取得了一些可喜的成果,但是想要治疗HIV还任重而道远。近日,中国科学院昆明动物研究所郑永唐课题组用HIV-1病毒标准株HIV-1NL4.3感染北平顶猴,首次创建了HIV-1感染北平顶猴艾滋病模型。该研究成果发表在《Science Bulletin》上。

PNAS:计算机模拟揭露 HIV 病毒体内传播细节,有望为治疗提供新途径

近日,芝加哥大学的科学家们揭露了 HIV 出芽的秘密,为战胜可怕的艾滋病提供了新途径。论文发表在《美国国家科学院学报》(PANS)上。