JAHA:高敏心肌肌钙蛋白T与首次缺血性卒中后复发性血管事件的关系

2021-05-13 MedSci原创 MedSci原创

hs-cTnT与首次轻度至中度缺血性卒中后3年内血管事件复发和死亡的风险增加存在剂量依赖性。这些结果支持了进一步研究hs‐cTnT在卒中后个体化风险分层中潜在作用的意义。

最近的证据表明,心肌肌钙蛋白水平是血管风险增加的一个标志。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估高敏心肌肌钙蛋白T (hs-cTnT)水平是否与首次轻度至中度缺血性卒中患者的复发性血管事件和死亡相关。

研究人员使用了来自柏林卒中前瞻性队列研究(PROSCIS‐B)的数据。研究人员计算了Cox比例风险回归分析,以评估研究入组时hs-cTnT水平(Roche Elecsys,参考上限为14ng/L)与主要结局(复发性卒中、心肌梗死和全因死亡复合事件)之间的相关性。

该研究共分析了562例患者(平均年龄为67岁[SD为13];38.6%为女性;美国国立卫生研究院卒中量表中位数=2;39.2%的患者hs‐cTnT高于参考值上限)。在平均3年的随访期间,89例(15.8%)患者发生了主要结局,包括40例(7.1%)复发性卒中,4例(0.7%)心肌梗死,51例(9.1%)全因死亡事件。在hs-cTnT水平高于参考值上限的患者中发生主要结局的几率更高(27.3% vs. 10.2%;调整后的风险比为2.0;95%CI为1.3-3.3),当比较最高和最低的hs-cTnT四分位数时,具有剂量反应关系(每100人每年15.2次 vs. 1.8次事件;调整后的风险比为4.8;95%CI为1.9-11.8)。这种关联在敏感性分析中保持一致,包括年龄匹配和性别分层。

由此可见,hs-cTnT与首次轻度至中度缺血性卒中后3年内血管事件复发和死亡的风险增加存在剂量依赖性。这些结果支持了进一步研究hs‐cTnT在卒中后个体化风险分层中潜在作用的意义。

原始出处:

Jan F. Scheitz.et al.High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.018326

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  5. 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  6. 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  7. 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topicList=[TopicDto(id=42558, encryptionId=3ce442558be, topicName=复发性血管事件)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sat Jan 01 13:21:24 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671427, encodeId=0ad916e142717, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Sun Sep 19 20:21:24 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806436, encodeId=935418064360c, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jun 24 05:21:24 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984501, encodeId=d1221984501a1, content=<a href='/topic/show?id=6e1b102408ab' target=_blank style='color:#2F92EE;'>#高敏心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102408, encryptionId=6e1b102408ab, topicName=高敏心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Thu Apr 14 13:21:24 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737159, encodeId=9eab1e371590e, content=<a href='/topic/show?id=6f9710240953' target=_blank style='color:#2F92EE;'>#高敏心肌肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102409, encryptionId=6f9710240953, topicName=高敏心肌肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a93234252832, createdName=yanjie6253_56072853, createdTime=Sun Nov 07 06:21:24 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268528, encodeId=ca40126852863, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490340, encodeId=b4451490340f5, content=<a href='/topic/show?id=72a651322e0' target=_blank style='color:#2F92EE;'>#心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51322, encryptionId=72a651322e0, topicName=心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1de58724110, createdName=wrj0124, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1909896, encodeId=9bb8190989697, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 03 04:21:24 CST 2022, time=2022-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643744, encodeId=8ab01643e44ad, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Dec 02 08:21:24 CST 2021, time=2021-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893379, encodeId=7b6d18933e99c, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Feb 27 14:21:24 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006656, encodeId=0aa62006656f2, content=<a href='/topic/show?id=3ce442558be' target=_blank style='color:#2F92EE;'>#复发性血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42558, encryptionId=3ce442558be, topicName=复发性血管事件)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sat Jan 01 13:21:24 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671427, encodeId=0ad916e142717, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Sun Sep 19 20:21:24 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806436, encodeId=935418064360c, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jun 24 05:21:24 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984501, encodeId=d1221984501a1, content=<a href='/topic/show?id=6e1b102408ab' target=_blank style='color:#2F92EE;'>#高敏心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102408, encryptionId=6e1b102408ab, topicName=高敏心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Thu Apr 14 13:21:24 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737159, encodeId=9eab1e371590e, content=<a href='/topic/show?id=6f9710240953' target=_blank style='color:#2F92EE;'>#高敏心肌肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102409, encryptionId=6f9710240953, topicName=高敏心肌肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a93234252832, createdName=yanjie6253_56072853, createdTime=Sun Nov 07 06:21:24 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268528, encodeId=ca40126852863, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490340, encodeId=b4451490340f5, content=<a href='/topic/show?id=72a651322e0' target=_blank style='color:#2F92EE;'>#心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51322, encryptionId=72a651322e0, topicName=心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1de58724110, createdName=wrj0124, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1909896, encodeId=9bb8190989697, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Jan 03 04:21:24 CST 2022, time=2022-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643744, encodeId=8ab01643e44ad, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdBy=05a2499, createdName=dzx0922889, createdTime=Thu Apr 14 13:21:24 CST 2022, time=2022-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737159, encodeId=9eab1e371590e, content=<a href='/topic/show?id=6f9710240953' target=_blank style='color:#2F92EE;'>#高敏心肌肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102409, encryptionId=6f9710240953, topicName=高敏心肌肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a93234252832, createdName=yanjie6253_56072853, createdTime=Sun Nov 07 06:21:24 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268528, encodeId=ca40126852863, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490340, encodeId=b4451490340f5, content=<a href='/topic/show?id=72a651322e0' target=_blank style='color:#2F92EE;'>#心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51322, encryptionId=72a651322e0, topicName=心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1de58724110, createdName=wrj0124, createdTime=Sat May 15 14:21:24 CST 2021, time=2021-05-15, status=1, ipAttribution=)]
    2021-05-15 zhaohui6731
  10. 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