Thorax:儿童和年轻人哮喘与全因死亡率的关系

2020-09-24 MedSci原创 MedSci原创

不论LLC和父母SES,哮喘与儿童和年轻人的死亡率增加有关。有必要进行进一步的研究以调查这种关联的可能机制。

研究表明,哮喘成人的全因死亡率增加。近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员旨在探究儿童和年轻人哮喘与全因死亡率之间的关系,并根据生命限制疾病(LLC)或父母的社会经济地位(SES)来探究死亡率差异。

这项基于登记的研究包括了1986年1月至2012年12月期间在瑞典出生的2775430名受试者,研究人员使用国家病人登记处(NPR)和处方药登记处确定了哮喘病例,并使用NPR确定了具有LLC受试者。出生时父母的SES(收入和教育程度)来自瑞典统计局。研究人员使用Cox比例风险回归模型估算了哮喘与全因死亡率之间的关联,并在调整后的模型中使用相互作用项按LLC或父母SES探究了效应修饰作用。

哮喘患者和非哮喘患者全因死亡率调整后的风险比(adjHR)为1.46(95%CI为1.33至1.62)。5至15岁的人群增长率最高。在没有LLC的哮喘患者中,adjHR仍然升高为1.33(95%CI为1.18至1.50),但与伴有LLC的哮喘患者有所不同(p=0.002),其adjHR为1.87(95%CI为1.57至2.22)。父母的SES并没有改变这种关联(收入,p=0.55;教育程度,p=0.83)。

这项研究表明,不论LLC和父母SES,哮喘与儿童和年轻人的死亡率增加有关。有必要进行进一步的研究以调查这种关联的可能机制。

原始出处:

Emma Caffrey Osvald,et al.Asthma and all-cause mortality in children and young adults: a population-based study.Thorax.2020.http://dx.doi.org/10.1136/thoraxjnl-2020-214655

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=889067, encodeId=349688906eee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200924/1f0d3a1b1b18443fa30de1daf0223787/f02372391ce2429baba98d30608a173e.jpg, createdBy=1b362235963, createdName=内科, createdTime=Tue Sep 29 07:38:47 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251532, encodeId=69bf12515325d, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Sep 26 14:58:59 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888474, encodeId=c6ba8884e43e, content=加强哮喘人群管理。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Sep 26 09:22:23 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888148, encodeId=3910888148c9, content=学习了😊😊😊😊, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Sep 25 06:56:53 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
    2020-09-29 内科

    学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=889067, encodeId=349688906eee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200924/1f0d3a1b1b18443fa30de1daf0223787/f02372391ce2429baba98d30608a173e.jpg, createdBy=1b362235963, createdName=内科, createdTime=Tue Sep 29 07:38:47 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251532, encodeId=69bf12515325d, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Sep 26 14:58:59 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888474, encodeId=c6ba8884e43e, content=加强哮喘人群管理。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Sep 26 09:22:23 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888148, encodeId=3910888148c9, content=学习了😊😊😊😊, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Sep 25 06:56:53 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=889067, encodeId=349688906eee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200924/1f0d3a1b1b18443fa30de1daf0223787/f02372391ce2429baba98d30608a173e.jpg, createdBy=1b362235963, createdName=内科, createdTime=Tue Sep 29 07:38:47 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251532, encodeId=69bf12515325d, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Sep 26 14:58:59 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888474, encodeId=c6ba8884e43e, content=加强哮喘人群管理。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Sep 26 09:22:23 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888148, encodeId=3910888148c9, content=学习了😊😊😊😊, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Sep 25 06:56:53 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
    2020-09-26 言西早

    加强哮喘人群管理。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=889067, encodeId=349688906eee, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200924/1f0d3a1b1b18443fa30de1daf0223787/f02372391ce2429baba98d30608a173e.jpg, createdBy=1b362235963, createdName=内科, createdTime=Tue Sep 29 07:38:47 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251532, encodeId=69bf12515325d, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Sat Sep 26 14:58:59 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888474, encodeId=c6ba8884e43e, content=加强哮喘人群管理。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sat Sep 26 09:22:23 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888148, encodeId=3910888148c9, content=学习了😊😊😊😊, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Sep 25 06:56:53 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
    2020-09-25 zb1235672

    学习了😊😊😊😊

    0

相关资讯

Medicine (Baltimore):口腔健康不良与哮喘、过敏性鼻炎和过敏性皮肤炎有关

最近,有研究人员评估了韩国一个大的代表性青少年人群中口腔健康与哮喘/过敏性鼻炎/特应性皮炎之间的关系。

JAMA:维生素D3补充不能降低哮喘患儿恶化风险

研究认为,对于持续哮喘且维生素D水平较低的患儿,补充维生素D3不能降低患者哮喘恶化风险

Eur Respir J:肥胖和正常体重哮喘患者哮喘药物分析

尽管FEV1较低且FEV1/FVC%较低,肥胖的哮喘患者使用的哮喘药物种类和ICS剂量均高于正常体重的哮喘患者。需要更好地了解导致药物使用增加的因素,以改善哮喘亚组的预后。

BMJ:哮喘患者自我管理模式对医疗干预和生活质量的影响

哮喘患者使用定期医疗支持的自我管理可减少医疗资源使用,并改善哮喘的严重程度和生活质量

ERS 2020:高剂量Enerzair Breezhaler可进一步减轻哮喘发作

一项最新研究显示,与中等剂量相比,高剂量Enerzair Breezhaler(醋酸茚达特罗/溴化格隆溴铵/糠酸莫米松)可显著降低哮喘发作。

BMJ:与儿童哮喘相关的空气及家庭因素研究

PM2.5是诱发儿童哮喘和持续性喘息的重要风险因素,其他相关的危险因素包括父母哮喘、父母社会经济地位和孕期吸烟