Cell Death Dis:研究揭示肥胖者烧伤后肝脏脂肪浸润的机制

2018-05-17 MedSci MedSci原创

严重烧伤的病态肥胖患者临床结局不佳,代谢后果加重,多器官功能障碍/衰竭发生率更高,死亡率明显增加。而这些不良结局的潜在机制知之甚少。由于肝脏是中枢代谢器官之一,研究假设肥胖患者的热损伤导致脂肪分解和肝脏脂肪浸润明显增加,导致肝细胞和细胞器的严重改变,从而导致肝损伤和代谢功能障碍严重增加。 使用全身20%表面积烧伤的肥胖小鼠模型进行实验。将C57BL/6小鼠随机分为低脂饮食(LFD)和高脂饮食

严重烧伤的病态肥胖患者临床结局不佳,代谢后果加重,多器官功能障碍/衰竭发生率更高,死亡率明显增加。而这些不良结局的潜在机制知之甚少。由于肝脏是中枢代谢器官之一,研究假设肥胖患者的热损伤导致脂肪分解和肝脏脂肪浸润明显增加,导致肝细胞和细胞器的严重改变,从而导致肝损伤和代谢功能障碍严重增加。

使用全身20%表面积烧伤的肥胖小鼠模型进行实验。将C57BL/6小鼠随机分为低脂饮食(LFD)和高脂饮食(HFD)假烧和烧伤组(每组n = 6),饲喂16周。热损伤7天后分别取收集门静脉和心脏血液及肝脏组织进行免疫印迹和免疫组织化学分析。肝脏的大体检查显示HFD饲喂和烧伤的小鼠有明显的脂质浸润。

结果证实,增强的ER应激和抑制Akt-mTOR信号传导失调的钙稳态,促进了HF-喂养和烧伤小鼠中ER-线粒体接触的减少和线粒体β-氧化的减少,导致严重的肝脏脂肪浸润和明显的肝损伤,因此增加发病率和死亡率。

综上所述,该研究结果表明,肥胖通过抑制β-氧化,诱导细胞损伤和随后的器官功能障碍而导致肝脏脂肪浸润。

原始出处:


Li Diao, Christopher Auger, et al., Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury. Cell Death Dis. 2018 May; 9(5): 530. doi:  10.1038/s41419-018-0531-z

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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Fri Jun 08 20:12:47 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317516, encodeId=661d31e516d2, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:39 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317515, encodeId=193231e515c4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:33 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317514, encodeId=5e4b31e51415, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:27 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317513, encodeId=48ac31e5138c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:13 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-08-02 chg121
  5. 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likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:33 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317514, encodeId=5e4b31e51415, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:27 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317513, encodeId=48ac31e5138c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:13 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-07-31 维他命
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likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:33 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317514, encodeId=5e4b31e51415, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:27 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317513, encodeId=48ac31e5138c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 22 11:00:13 CST 2018, time=2018-05-22, status=1, ipAttribution=)]
    2018-06-08 zwjnj2

    认真学习天天学习

    0

  7. 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    2018-05-22 Y—xianghai

    学习了长知识

    0

  8. 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    2018-05-22 Y—xianghai

    学习了长知识

    0

  9. 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    2018-05-22 Y—xianghai

    学习了长知识

    0

  10. 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    2018-05-22 Y—xianghai

    学习了长知识

    0

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近日,一项刊登在国际著名杂志Science上的研究报告中,来自德克萨斯大学等机构的科学家们通过研究发现,在脂肪细胞分化期间,NAD+的合成和消耗或能整合葡萄糖代谢和基因转录过程;文章中,研究人员深入阐明了机体中的葡萄糖如何转化成为脂肪,相关研究或为后期研究人员开发新型疾病疗法提供了新的思路和方向。

J Clin Invest:新研究揭示胰岛素抵抗与脂肪组织炎症的因果关系

肥胖诱导的胰岛素抵抗是2型糖尿病、高脂血症、心血管疾病和一些癌症类型发生的主要风险因素,肥胖引起胰岛素抵抗的机制到目前为止仍不明确。许多研究表明炎症与局部和系统性胰岛素抵抗的发生有关,特别是当炎症发生在白色脂肪组织当中,但是这些事件的因果关系还不清楚。在最近发表在国际学术期刊JCI上的一项研究中,来自瑞士的研究人员发现脂肪组织的胰岛素抵抗导致了局部炎症的发生,并非炎症导致了脂肪组织的胰岛素抵抗。

PLOS ONE:我国夜班工作人员的肥胖概况

最近,来自香港中文大学的研究人员进行了一项探究,旨在使用中国夜班工人的前瞻性队列研究的基线信息,来评估夜班工作类型与不同肥胖指数之间的关联。

PLOS ONE:食用酵母产生的寡糖具有免疫调节作用

由于炎症是与肥胖相关代谢功能障碍的发生有关的潜在机制之一,来自莱顿大学医学中心的研究人员进行了一项探究,旨在确定膳食补充MOS对纤瘦的和饮食诱导的肥胖小鼠的炎症和代谢稳态的影响。