Clinical Nutrition: 营养不良对胰腺切除术后结果的影响

2022-07-08 xuyihan MedSci原创

营养不良是一个描述健康状况的用语,由不适当或不足饮食所造成。通常指的是起因于摄入不足、吸收不良或过度损耗营养素所造成的营养不足,但也可能包含由于暴饮暴食或过度的摄入特定的营养素而造成的营养过剩。

营养不良可能会影响接受腹部大手术的患者的术后预后情况,事实上,显着的体重减轻 (WL) 在胃肠道癌症中很常见,通常是由于厌食、恶病质或吸收不良导致的。营养不良的发生率在患有胰腺肿瘤,特别是胰腺导管腺癌 (PDAC) 的情况下能达到 85%。一些研究已经强调了术前营养不良与胰腺手术后并发症之间的关系。本项研究旨在探究术前营养不良在接受胰腺切除术的患者术后过程中的作用。

这是一项回顾性研究,涉及 488 名接受胰腺切除术的患者。对134名有中度或重度营养不良风险 (M/S-MAL) 的患者应用熵平衡的概念,以获得等于354名营养不良风险为零或低风险的患者 (N/L-MAL) 的队列。重新加权方案分两步进行。在第一次重新加权时,两个队列被同质化。在第 2 次重新加权中,两个队列通过术前饮食支持匹配可改变的因素。熵平衡用 d 值评估。

M/S-MAL组包括BMI (d<0.750)、血红蛋白 (d=0.671)、血清白蛋白 (d=0.554)、总蛋白 (d=0.381) 值较低的患者。M/S-MAL组患者更频繁的出现黄疸 (d=0.445) 或背痛 (d=0.366)。M/S-MAL组的胰十二指肠切除术(d=0.440)和血管切除术(d=0.620)的实施频率更高。在 N/L-MAL 组中,残余胰腺更常见(d=0.527),Wirsung管扩张的概率也更高(d=0.459)。M/S-MAL中胰腺导管腺癌的发生率较高(d=0.399)。第一次加权后,M/S-MAL 患者的综合并发症指数 (CCI) 较高(MD = 5.5;0.3 至 10.7)。

本项研究证实营养不良的纠正可以在降低接受胰腺切除术的患者的并发症严重程度、住院时间和出院类型方面发挥作用。

原始出处:

ClaudioRicci. Et al. Effect of malnutrition on postoperative results after pancreatic resection: an entropy balancing analysis. Clinical Nutrition.2022.

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    2022-07-05 zll0628

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