Front Microbiol:出门晒晒太阳吧!补充维生素D还能改善肠道健康

2019-10-31 徐悦 生物探索

不列颠哥伦比亚大学Bruce Vallance博士领导的研究团队,对21名健康的女性进行试验,以了解通过将皮肤暴露于UVB光线下增加维生素D含量是否会改变肠道菌群的组成。

深秋已至,阳光也变得格外温暖。加拿大不列颠哥伦比亚大学的研究人员发现:适当地晒晒太阳不仅能够促进维生素D的吸收,还能够改善人体的肠道微生物组。这是第一个证明日光浴会改变肠道菌群的研究,该研究结果发表在《微生物学前沿》(Frontiers in Microbiology)上。

从小妈妈就告诉我,多晒晒阳光更加健康(可能在妈妈眼中酱油色的皮肤更健康)。但是对于那些生活在高纬度地区的人来讲,漫长的冬季不仅意味着寒冷还有随之而来的黑夜。而人们只有暴露在阳光下才能达到80%的维生素D需求,因此很多生活在高纬度地区的人因为暴露的UVB(波长在290~320nm之间的紫外线)有限,罹患诸如多发性硬化症和炎症性肠病(IBD、MS)等疾病的风险更高。

不列颠哥伦比亚大学Bruce Vallance博士领导的研究团队,对21名健康的女性进行试验,以了解通过将皮肤暴露于UVB光线下增加维生素D含量是否会改变肠道菌群的组成。在一周的时间内,有12名参与者进行了3次一分钟的全身UVB暴露。其余9名参与者在试验开始前的三个月内一直服用维生素D补充剂。



研究结果发现,在暴露于UVB之前,接受UVB暴露女性的肠道微生物组比那些服用常规维生素D补充剂的女性要少。在接受UVB暴露后,她们体内微生物组的丰富度和均匀度提高到与补充组的水平,而服用维生素D补充剂体内的肠道微生物并没有明显改变。这意味着暴露在阳光下的人更为健康。

值得一提的是,在接受UVB暴露的一组中,增加的肠道菌群都是健康的“有益细菌”,在炎症性患者体内,这些“健康”细菌的数量较少。因此带病人出去晒晒太阳也是不错的选择。


微生物分析比较UVB暴露前后的研究队列

Vallance博士表示:“在这项研究中,我们也发现了与血液中维生素D水平的相关性,紫外线暴露后血液中维生素D水平增加。这表明维生素D至少部分介导了UVB诱导的肠道微生物组变化。”同时,研究人员也找到了相关数据证明紫外线能够推动维生素D合成来调节改善人类肠道微生物组的组成。

人类的微生物组组成会出现季节性的波动,这可能与全年维生素D水平的吸收波动相关。虽然微生物组的季节性变化可能不会对健康个体产生明显影响,但对于免疫功能低下的人来说,季节性的慢性炎症会让人们的生活品质大打折扣。

露于UVB光线很可能首先改变皮肤的免疫系统,然后更系统地改变免疫系统,这反过来又会影响肠道环境对各种细菌的有利程度。这项研究的结果对正在接受UVB光疗的人们产生了影响,并确定了一种新型的皮肤肠道轴,它可能有助于UVB光暴露在MS和IBD等炎性疾病中的保护作用。

原始出处:Else S. Bosman1, Arianne Y. Albert, Harvey Lui, et al. Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome. Front. Microbiol., 24 October 2019

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1951639, encodeId=cb0f1951639f5, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sat Jun 13 02:58:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918898, encodeId=74561918898a9, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 19 17:58:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767711, encodeId=0a451e67711af, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon May 25 18:58:00 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084562, encodeId=d4f3208456251, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Apr 30 21:58:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857845, encodeId=cf89185e84528, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 03 01:58:00 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2020-06-13 amyloid
  2. [GetPortalCommentsPageByObjectIdResponse(id=1951639, encodeId=cb0f1951639f5, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sat Jun 13 02:58:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918898, encodeId=74561918898a9, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 19 17:58:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767711, encodeId=0a451e67711af, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon May 25 18:58:00 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084562, encodeId=d4f3208456251, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Apr 30 21:58:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857845, encodeId=cf89185e84528, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 03 01:58:00 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2020-04-19 sunylz
  3. [GetPortalCommentsPageByObjectIdResponse(id=1951639, encodeId=cb0f1951639f5, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sat Jun 13 02:58:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918898, encodeId=74561918898a9, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 19 17:58:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767711, encodeId=0a451e67711af, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon May 25 18:58:00 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084562, encodeId=d4f3208456251, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Apr 30 21:58:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857845, encodeId=cf89185e84528, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 03 01:58:00 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1951639, encodeId=cb0f1951639f5, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sat Jun 13 02:58:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918898, encodeId=74561918898a9, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 19 17:58:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767711, encodeId=0a451e67711af, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon May 25 18:58:00 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084562, encodeId=d4f3208456251, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Apr 30 21:58:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857845, encodeId=cf89185e84528, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 03 01:58:00 CST 2019, time=2019-11-03, status=1, ipAttribution=)]
    2020-04-30 xjy02
  5. [GetPortalCommentsPageByObjectIdResponse(id=1951639, encodeId=cb0f1951639f5, content=<a href='/topic/show?id=bd5259e63d9' target=_blank style='color:#2F92EE;'>#晒太阳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59763, encryptionId=bd5259e63d9, topicName=晒太阳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Sat Jun 13 02:58:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918898, encodeId=74561918898a9, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Apr 19 17:58:00 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767711, encodeId=0a451e67711af, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon May 25 18:58:00 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084562, encodeId=d4f3208456251, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Apr 30 21:58:00 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857845, encodeId=cf89185e84528, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 03 01:58:00 CST 2019, time=2019-11-03, status=1, ipAttribution=)]

相关资讯

关于维生素D的应用 这几个问题你要知道

几十年来,维生素D缺乏症一直是全世界关注的健康问题。许多国家实施了维生素D补充和食品强化的指导方针,但预防措施不够充分。自20世纪20年代以来,维生素D被认为在预防和治疗佝偻病方面是有效的,但对骨骼健康的最佳补充仍然不清楚。维生素D也常用来配合糖皮质激素(GC)在风湿病、肾病、血液病及肿瘤等领域的应用。

维生素D水平低与卒中,谁是因谁是果?

有研究表明维生素D与心血管疾病的发病机制有关。但是,先前关于维生素D与卒中相关性的研究结果并不一致。近期,《Stroke》杂志上发表了一项大型前瞻性队列研究,探讨维生素D与卒中的相关性。RS研究(Rotterdam Study),是一项基于人群的前瞻性研究,测量了9680名年龄≥45岁的参与者(56.8%为女性)在1997年至2008年间的血清25-羟基维生素D浓度,调查了基线期卒中患病(prev

2019 ASBMR:服用高剂量的维生素D与动脉钙化无关

佛罗里达州奥兰多市举办的2019年美国骨与矿物质研究学会(ASBMR)年会上进行的次要分析显示,无论维生素D的剂量如何,健康的中年男女都不会发生血管钙化。

Ear Nose Throat J:α-乙酸生育酚在鼻呼吸功能作用研究

原发性萎缩性鼻炎是一种鼻部和副鼻窦疾病,并具有鼻腔和副鼻窦粘膜功能的渐进性丧失特征,病因是由于纤毛粘膜上皮逐渐破坏、浆液腺体萎缩和骨结构丢失。最近有研究人员基于主观和客观数据,评估了α-乙酸生育酚(维生素E)在原发性萎缩性鼻炎治疗中的影响。研究人员分析了α-乙酸生育酚治疗前后6个月的鼻内镜下鼻粘膜核、鼻前鼻测定仪和鼻黏膜睫状体清除术情况。研究人员使用成对样本t测试(95%CI,P<0.05)