J Pineal Res:褪黑激素可以有效帮助癌症患者

2017-09-16 AFn 来宝网

【滞后药物可以帮助癌症患者】研究表明,癌症药物的痛苦副作用可以通过减轻时差滞后的药物来解决。

【滞后药物可以帮助癌症患者】研究表明,癌症药物的痛苦副作用可以通过减轻时差滞后的药物来解决。

这种称为褪黑素的药物似乎可以预防化疗对神经的损伤。

大鼠的研究显示,它阻止对神经健康的有害影响。

专家说,这些发现有助于科学家更多地了解如何限制化疗的副作用。

化疗痛

来自爱丁堡大学和阿伯丁大学的科学家专注于称为化疗诱发的神经性疼痛(CINP)的常见病症。

CINP影响近70%接受化疗的患者,并可能对生活质量产生严重影响。

“这是一个真正未满足需求的领域,迫切需要新的治疗方法,我们正在积极探索一个早期临床研究,这些令人兴奋的实验室研究结果可能会对化疗患者产生直接益处。”Lesley Colvin教授说。

研究表明,化疗前给予的褪黑激素限制了对神经细胞的破坏作用和疼痛症状的发展。

当CINP开发时,褪黑激素没有减轻疼痛,这表明其潜在的益处可能是预防而不是治愈。

重要的是,褪黑激素治疗并不干扰化疗对人乳腺癌卵巢癌细胞有益的抗癌作用。

“这些发现非常令人兴奋,并表明褪黑激素可以通过保护神经细胞线粒体来预防CINP。我们的下一步将是通过研究褪黑激素在其他还涉及线粒体损伤的疼痛病症中的作用来进一步测试这一理论。”

线粒体

研究结果还表明,褪黑激素减少化疗对被称为线粒体的神经细胞重要部位造成的损伤。

专家指出,减少对这些细胞能量中心的伤害可能是预防CINP的关键。

原始出处:Helen F. Galley, Barry McCormick, Kirsten L. Wilson, et al. Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat. Journal of Pineal Research (2017).

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    2017-09-18 明天会更好!

    谢谢分享.感觉收获很大!!!

    0

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    2017-09-17 惠映实验室

    学习了.谢谢.

    0

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    2017-09-17 大爰

    学习了谢谢分享!!

    0

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    2017-09-17 明月清辉

    谢谢分享.学习了

    0

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    2017-09-16 131****2916

    不错的文章值得学习

    0

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