Nat Commun:内源性大麻素系统?肠道菌群对抑郁的影响机制被进一步发现。

2020-12-13 MedSci原创 MedSci原创

抑郁症是一种严重的精神疾病。近期研究发现,肠道细菌群落的失衡会导致内源性大麻素分泌的减少,从而诱发抑郁症形成。通过补充相应细菌,恢复肠道菌群平衡,能够缓解抑郁症状的产生。

抑郁症是一种严重的精神疾病,影响全世界超过2.64亿人群。了解其机制对于制定有效的治疗策略至关重要。近期,巴斯德研究所,Inserm研究所和CNRS的科学家最近进行的一项研究表明,肠道细菌群落的失衡会导致某些代谢产物减少,从而在小鼠中产生类似抑郁的行为。这些发现表明健康的肠道菌群有助于正常的大脑功能,并发表在2020年12月11日的《自然通讯》杂志上。

肠道菌群是人体最大的细菌库。越来越多的研究表明,宿主和肠道微生物群间属于互利互动的系统。其中,宿主的情绪障碍与肠道微生物群的损害之间也存在明显的关联。在这项研究中,科学家发现肠道微生物群与氟西汀(一种经常被用作抗抑郁剂的分子)的功效之间存在相关性。于是他们以此为基础,进一步探究抑郁症的影响机制。

通过动物模型研究,他们发现,慢性压力带来的肠道菌群的变化会导致小鼠产生抑郁症样的行为,特别是通过导致血液和大脑中的脂质代谢物减少。这些脂质代谢物,也被称为内源性大麻素,是协调体内的信号调节的重要通信系统。内源性大麻素能够与海马体中的特定受体(THC)结合,对记忆和情绪的形成起到关键作用。而慢性压力使肠道菌群产生的代谢物即内源性大麻素减少,使得这套系统传递信息受阻,从而导致了抑郁症样行为的产生。

肠道菌群的改变减少内源性大麻素的代谢,导致小鼠抑郁症样行为的产生

进而,科学家通过给予这些“抑郁”小鼠用同样的细菌进行口服治疗,结果发现,在小鼠血液和脑中内源性大麻素代谢物的含量上升的情况下,海马区神经元功能得到恢复,抑郁症样的行为同样得到缓解。因此,这提示这些细菌有望通过调节肠道菌群的方式,作为一种抗抑郁药物发挥作用。

给予口服细菌补剂恢复了小鼠抑郁症样行为

这项研究揭示了肠道微生物群在大脑功能中所发挥的作用,对我们理解宿主与肠道菌群的相互作用开拓了新的视野,也为抑郁症及其他神经系统疾病的预防和治疗提供了新思路和启示。

 

原文链接:, et al. Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system. Nat Commun. Dec 11, 2020.

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createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
    2021-03-25 1225f870m98(暂无昵称)

    不错的研究

    0

  4. 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  5. 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  6. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907787, encodeId=c9f790e787dd, content=慢性压力会改变<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>,从而减少<a href='/topic/show?id=19a81040e72a' target=_blank style='color:#2F92EE;'>#内源性**素#</a>的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=104077, encryptionId=19a81040e72a, topicName=内源性**素)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
    2020-12-14 kcb069
  7. [GetPortalCommentsPageByObjectIdResponse(id=1884841, encodeId=13a918848414b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 21 08:02:17 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087851, encodeId=e97e208e851ea, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Jan 16 00:02:17 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950955, encodeId=de6c9509558b, content=不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Mar 25 11:11:29 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682049, encodeId=f43216820499e, content=<a href='/topic/show?id=15593040e9a' target=_blank style='color:#2F92EE;'>#内源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30407, encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Sat Jul 03 22:02:17 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744761, encodeId=33811e44761b4, content=<a href='/topic/show?id=d6cc304149c' target=_blank style='color:#2F92EE;'>#内源性大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30414, encryptionId=d6cc304149c, topicName=内源性大麻素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153235436253, createdName=jml2021, createdTime=Fri Jan 22 08:02:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272768, encodeId=a9e812e2768ad, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361194, encodeId=6244136119460, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392422, encodeId=c49613924228c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907787, encodeId=c9f790e787dd, content=慢性压力会改变<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>,从而减少<a href='/topic/show?id=19a81040e72a' target=_blank style='color:#2F92EE;'>#内源性**素#</a>的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=104077, encryptionId=19a81040e72a, topicName=内源性**素)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1884841, encodeId=13a918848414b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 21 08:02:17 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087851, encodeId=e97e208e851ea, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Jan 16 00:02:17 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950955, encodeId=de6c9509558b, content=不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Mar 25 11:11:29 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682049, encodeId=f43216820499e, content=<a href='/topic/show?id=15593040e9a' target=_blank style='color:#2F92EE;'>#内源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30407, encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Sat Jul 03 22:02:17 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744761, encodeId=33811e44761b4, content=<a href='/topic/show?id=d6cc304149c' target=_blank style='color:#2F92EE;'>#内源性大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30414, encryptionId=d6cc304149c, topicName=内源性大麻素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153235436253, createdName=jml2021, createdTime=Fri Jan 22 08:02:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272768, encodeId=a9e812e2768ad, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361194, encodeId=6244136119460, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392422, encodeId=c49613924228c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907787, encodeId=c9f790e787dd, content=慢性压力会改变<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>,从而减少<a href='/topic/show?id=19a81040e72a' target=_blank style='color:#2F92EE;'>#内源性**素#</a>的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=104077, encryptionId=19a81040e72a, topicName=内源性**素)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1884841, encodeId=13a918848414b, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 21 08:02:17 CST 2020, time=2020-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087851, encodeId=e97e208e851ea, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, 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createdName=diushouji, createdTime=Sat Jul 03 22:02:17 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744761, encodeId=33811e44761b4, content=<a href='/topic/show?id=d6cc304149c' target=_blank style='color:#2F92EE;'>#内源性大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30414, encryptionId=d6cc304149c, topicName=内源性大麻素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153235436253, createdName=jml2021, createdTime=Fri Jan 22 08:02:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272768, encodeId=a9e812e2768ad, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361194, encodeId=6244136119460, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392422, encodeId=c49613924228c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907787, encodeId=c9f790e787dd, content=慢性压力会改变<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>,从而减少<a href='/topic/show?id=19a81040e72a' target=_blank style='color:#2F92EE;'>#内源性**素#</a>的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=104077, encryptionId=19a81040e72a, topicName=内源性**素)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
    2020-12-14 Jessica

    慢性压力会改变#肠道菌群#,从而减少#内源性**素#的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。

    0

  10. 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createdName=liuli5079, createdTime=Sat Jan 16 00:02:17 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950955, encodeId=de6c9509558b, content=不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d4d2326628, createdName=1225f870m98(暂无昵称), createdTime=Thu Mar 25 11:11:29 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682049, encodeId=f43216820499e, content=<a href='/topic/show?id=15593040e9a' target=_blank style='color:#2F92EE;'>#内源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30407, encryptionId=15593040e9a, topicName=内源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b46b27929604, createdName=diushouji, createdTime=Sat Jul 03 22:02:17 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744761, encodeId=33811e44761b4, content=<a href='/topic/show?id=d6cc304149c' target=_blank style='color:#2F92EE;'>#内源性大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30414, encryptionId=d6cc304149c, topicName=内源性大麻素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153235436253, createdName=jml2021, createdTime=Fri Jan 22 08:02:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272768, encodeId=a9e812e2768ad, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361194, encodeId=6244136119460, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392422, encodeId=c49613924228c, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Dec 14 15:02:17 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907787, encodeId=c9f790e787dd, content=慢性压力会改变<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>,从而减少<a href='/topic/show?id=19a81040e72a' target=_blank style='color:#2F92EE;'>#内源性**素#</a>的减少,而内源性**素是协调体内的信号调节的重要通信系统,对记忆和情绪的形成起到关键作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=104077, encryptionId=19a81040e72a, topicName=内源性**素)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Dec 14 10:45:29 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907691, encodeId=1c6590e69103, content=肠道菌群对抑郁的影响机制被进一步发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Sun Dec 13 22:29:51 CST 2020, time=2020-12-13, status=1, ipAttribution=)]
    2020-12-13 Lizhihua6

    肠道菌群对抑郁的影响机制被进一步发现。

    0

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