Clin Cancer Res：肠道菌群可预测晚期直肠癌患者对新辅助放化疗的反应性！

2021-01-20 MedSci原创 MedSci原创

肠道菌群（GM）参与抗肿瘤免疫治疗和化疗反应，然而，关于肠道菌群在预测局部晚期直肠癌(LARC)患者新辅助放化疗(nCRT)疗效方面的循证研究仍较少。该项前瞻性的纵向研究旨在评估肠道微生物群预测nCR

肠道菌群（GM）参与抗肿瘤免疫治疗和化疗反应，然而，关于肠道菌群在预测局部晚期直肠癌(LARC)患者新辅助放化疗(nCRT)疗效方面的循证研究仍较少。该项前瞻性的纵向研究旨在评估肠道微生物群预测nCRT反应的可行性。

研究人员收集了84位LARC患者在nCRT治疗前后的167份粪便样本和31位健康人的粪便样本进行16S rRNA测序。根据对nCRT的病理反应将患者分为有应答组和无应答组。确定了与nCRT反应相关的微生物生物标志物后，研究人员根据37位患者的基线样本构建了一个随机森林分类器并在另一组47位患者中进行了验证。

LARC患者和健康对照治疗的基线菌群

LARC患者治疗后的菌群

研究人员观察到显著的微生物群改变，表现为LARC相关病原菌减少和nCRT期间乳酸菌和链球菌增多。此外，应答者和无应答者的基线样本中存在显著的微生物差异。与丁酸酯生产相关的微生物，包括罗氏弧菌、多尔氏菌和厌氧棒杆菌，在应答者中为优势菌群；而红蝽杆菌和梭形杆菌在无应答者中为优势菌群。

反应-预测分类器的表现

选择了10个生物标志物作为反应-预测分类器，包括多尔氏菌、厌氧棒杆菌和链球菌，在训练队列中的AUC高达93.57%（95% CI 85.76%-100%），在验证队列中AUC为73.53%(58.96%-88.11%)。

综上，肠道微生物群为预测患者对nCRT治疗的反应提供了新的潜在生物标志物，该结果对这类患者的临床治疗管理有重要的指导意义。

原始出处：

Yi Yuxi,Shen Lijun,Shi Wei et al. Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study. Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-3445.

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2021-11-06 徐岩

#辅助放化疗#

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2021-11-07 charl1234576

#新辅助#

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2021-10-08 12499e01m47暂无昵称

#反应性#

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2021-01-27 JMR666

11111

73 0
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2021-01-22 yzh399

#放化疗#

29 0
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2021-01-22 1249897bm37(暂无昵称)

#肠道菌#

30 0
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2021-01-22 lisa439

#新辅助放化疗#

45 0
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createdName=charl1234576, createdTime=Sun Nov 07 03:18:04 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022855, encodeId=a4fa202285556, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Fri Oct 08 10:18:04 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920250, encodeId=667f92025052, content=11111, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=233e5432985, createdName=JMR666, createdTime=Wed Jan 27 10:42:49 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287951, encodeId=7452128e9515d, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392424, encodeId=f2911392424ac, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417403, encodeId=87f5141e40303, content=<a href='/topic/show?id=511758698dd' target=_blank style='color:#2F92EE;'>#新辅助放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58698, encryptionId=511758698dd, topicName=新辅助放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e20a3269889, createdName=lisa439, createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918608, encodeId=71fe9186086e, content=11111, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201215/e3e7faa007024c79aabbddd5f3c859e8/bbf4547d810244ab879ee1beefdd800b.jpg, createdBy=4b6a5155323, createdName=146a55a0m33暂无昵称, createdTime=Thu Jan 21 07:02:42 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918584, encodeId=917a9185847a, content=这篇文章不错，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acfe5454566, createdName=ms1000001332061167, createdTime=Wed Jan 20 23:35:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918567, encodeId=76b291856e36, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Wed Jan 20 22:33:01 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
2021-01-21 146a55a0m33暂无昵称

11111

70 0
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createdName=charl1234576, createdTime=Sun Nov 07 03:18:04 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022855, encodeId=a4fa202285556, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Fri Oct 08 10:18:04 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920250, encodeId=667f92025052, content=11111, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=233e5432985, createdName=JMR666, createdTime=Wed Jan 27 10:42:49 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287951, encodeId=7452128e9515d, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392424, encodeId=f2911392424ac, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417403, encodeId=87f5141e40303, content=<a href='/topic/show?id=511758698dd' target=_blank style='color:#2F92EE;'>#新辅助放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58698, encryptionId=511758698dd, topicName=新辅助放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e20a3269889, createdName=lisa439, createdTime=Fri Jan 22 13:18:04 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918608, encodeId=71fe9186086e, content=11111, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201215/e3e7faa007024c79aabbddd5f3c859e8/bbf4547d810244ab879ee1beefdd800b.jpg, createdBy=4b6a5155323, createdName=146a55a0m33暂无昵称, createdTime=Thu Jan 21 07:02:42 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918584, encodeId=917a9185847a, content=这篇文章不错，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acfe5454566, createdName=ms1000001332061167, createdTime=Wed Jan 20 23:35:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918567, encodeId=76b291856e36, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Wed Jan 20 22:33:01 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
2021-01-20 ms1000001332061167

这篇文章不错，学习

73 0
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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Wed Jan 20 22:33:01 CST 2021, time=2021-01-20, status=1, ipAttribution=)]
2021-01-20 医鸣惊人

认真学习了

83 0

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